1、December 2024Longevity&Healthy AgeingTechnology to live longer and healthier Page/2 Pan-European early-stage venture capital firm with a dedicated Health&TechBio investment team.Speedinvest is one of Europes most active Seed funds with 40+investors based in Berlin,London,Munich,Paris,and Vienna.Our

2、six sector-focused teams are the first to fund Europes most innovative startups,and our in-house operational pros offer founders hands-on support throughout every stage of their journeys.CoachHub,tide,moove and Schttflix are among our portfolio of 300+companies.We believe the next decade will be tra

3、nsformational for health&techbio.Advances in computing,technology,and biology are compounding at a dizzying pace,yet healthcare remains one of the least digitized sectors.The case for change has never been clearer.One of the largest global insurance and asset management providers.Established in 1831

4、,it is present in over 50 countries in the world,with a total premium income of 82 billion in 2023.With 82,000 employees serving 70 million customers,the Group has a leading position in Europe and a growing presence in Asia and Latin America.At the heart of Generalis strategy is its Lifetime Partner

5、 commitment to customers,achieved through innovative and personalised solutions,best-in-class customer experience and its digitized global distribution capabilities.The Group has fully embedded sustainability into all strategic choices,with the aim to create value for all stakeholders while building

6、 a fairer and more resilient society.Global startup&venture capital intelligence platform.Dealroom.co is the foremost data provider on startup,early-stage and growth company ecosystems in Europe and around the globe.Founded in Amsterdam in 2013,we now work with many of the worlds most prominent inve

7、stors,entrepreneurs and government organizations to provide transparencDealroom.co is a global intelligence platform for discovering and tracking the most promising companies,technologies and ecosystems.Clients include many of the worlds foremost organizations such as Accel,Index Ventures,McKinsey,B

8、CG,Deloitte,Google,AWS,Microsoft,Stripe.Dealroom partners closely with local tech ecosystem development agencies and enablers,to create a comprehensive multidimensional blueprint of the tech ecosystem,including capital,talent,innovation,entrepreneurship and overall economic dynamism.Page/3 Longevity

9、&Healthy Ageing defined.Healthy AgeingStartups that develop solutions promoting physical,cognitive,and emotional well-being for older adults,incorporating longevity strategies and technologies to optimize health throughout the ageing process.Silver Economy Startups that design products and services

10、catering to the aging population,from health and wellness to financial services,housing,and lifestyle enhancements tailored to seniors evolving needs.-Financial wellbeing-End of life planning-Senior protection-Service portalsSilver HealthStartups creating tools and services that address the health n

11、eeds of older adults.-Care recruitment and management platforms-Elderly care platforms-Preventative health(clinics,wearables,testing etc.)-Digital tools for age-related conditions-Fall and emergency detection-Senior mental healthVirtual AssistantsType of AI agent that interacts with patients or phys

12、icians through NLP.Less autonomous than agents,executes tasks based on commands.Silver TechLongevityTechnologies that focus on extending lifespan and enhancing the quality of life,ranging from biotech innovations to personalized health tools aimed at delaying ageing and age-related diseases.-Drug di

13、scovery for age-related conditions-Genetic testing-Cell repair and regeneration-Cellular clean-up and maintenance-Genetic modifications Page/3 Source:Dealroom.coPage/3 Dealroom.coSource:Page/3 Page/4 Key takeawaysIn 2024,US longevity startups have raised two times more than European ones.While life

14、expectancy has nearly doubled since the 1870s,it has been flattening in the last 20 years,and the proportion of healthy years has remained unchanged in the past decade.Novel medical practices including modifying genes and cells intends to slow down aging,an example is Altos Labs which raised a recor

15、d high$3B round in 2022.The ageing population is reshaping global health and economic landscapes,with older adults requiring more services to address caregiving needs,chronic diseases,and financial insecurities.Tools for formal and informal caregivers,for seniors mental health,end of life planning a

16、nd management of age related disease improve care efficiency,independence,and well-being while easing health and economic pressures.Within the Healthy Ageing sector,longevity companies have historically attracted most funding,with the exception of 2021-2022 with strong activity for Silver health.Hea

17、lthy Ageing startups develop solutions promoting physical,cognitive,and emotional well-being for older adults,incorporating longevity strategies and technologies to optimize health throughout the ageing process.VC funding in European healthy ageing by segmentVC funding in longevity startups per regi

18、onNumber of VC rounds in Senior Mental Health startups$01m(pre-seed)$14m(seed)$415m(series A)$1540m(series B)VC funding in European Healthy Ageing by segment Longevity Silver Health ProjectionNumber of VC rounds in Senior Mental Health startups$01m(pre-seed)$14m(seed)$415m(series A)$1540m(series B)V

19、C funding in longevity startups per region Europe USDealroom.coSource:Page/5 1Healthy Ageing2VC Trends3Silver Health 4Silver Economy5LongevityPage/6 Life expectancy has more than doubled since the 1870s to reach over 70 years,driven by tech and medical advances.This evolutionary-level progression,un

20、paralleled in the rest of human history,has largely been driven by technology.Key technological developments include:Clean water and sanitation with modern sewage systems and clean drinking water.Vaccination campaigns that eradicated diseases like smallpox and significantly reduced polio,measles,and

21、 other infectious diseases.In the last 50 years this saved an estimated 154 million lives,the majority infants.Antibiotics and Anti-Infectives,such as Penicillin which revolutionized the treatment of bacterial infections.Nutrition and Food Security:advanced in agritech from fertilizers to mechanizat

22、ions improved food production,reducing famine and malnutrition globally.Life expectancyBy birth yearDealroom.co,World Health Organization,UN WPP 2022Source:Page/7 By 2050,people aged 55+will represent 45%of the population,up from 28%in 2001,due to longer lifespan and lower birth rates.The ageing pop

23、ulation will require more services to ensure good living standards,caregiving,and management of age-related diseases.This demographic shift will further exacerbate to financial and connectivity/isolation challenges and present new reality for employers.By 2042,37%of Europes workforce is projected to

24、 be aged 50 or older.The economic implications include greater pressure on public pension funds and social security spending,alongside reduced overall productivity.Population by age groups in the EUIn millions,observed(2001-2019)and projected(2020-2100 data)55years55-64years65-74years75-84years 85ye

25、ars50045040035030025020015010050Our world in data,UN Population Division(2022),Eurostat-EUROPOP2019-Population projections at national level(2019-2100)Source:Page/8 Source:Dealroom.coWorldbank(2021)*Welfare states are highlighted,the UK is established on a mixed-welfare model.Welfare states such as

26、Spain and Italy have high out-of-pocket healthcare spending despite significant public expenditure,showing a struggle to meet patient needs.10.2%9.3%7.9%7.7%7.1%11.0%8.0%9.0%17.0%18.0%Healthcare spending as a%of GDP per capita Out-of-pocket spending as a%of total healthcare spendingDealroom.coWorldb

27、ank(2021)*Welfare states are highlighted,the UK is established on a mixed-welfare model.Source:Page/9 380+startups across 10 segments supporting Healthy Ageing.Explore the landscapePage/10 1Healthy Ageing2VC Trends3Silver Health 4Silver Economy5LongevityPage/11 Healthy Ageing startups in Europe alre

28、ady raised$460M this year,projected to surpass 2023.Late-stage funding has however been absent since 2022.CompanyRoundSegmentSub-segment63.5M Series BBiotech x longevityCell repair and regeneration$75.0m Series DDigital health x longevityDigital tools for age-related conditions$66.0m Series DBiotech

29、 x longevityNutrition and supplements29.2mEarly VCDigital health x silver healthDigital tools for age-related conditions$16.0mSeedBiotech x longevityGenetic testing and therapeuticsVC funding in European Healthy AgeingSelected rounds in 2024 view online$01m(pre-seed)$14m(seed)$415m(series A)$1540m(s

30、eries B)$40100m(series C)$100250m(mega rounds)$250m+(mega+)ProjectionDealroom.coData as of Nov 25th 2024.Source:Page/12 Longevity has historically attracted most funding,with the exception of 2021-2022 with strong activity for Silver health.As a segment,Healthy Ageing has grown more than ten fold in

31、 the past decade.VC funding in European Healthy Ageing by segmentDealroom.coData as of Nov 25th 2024.Source:Page/13 Growth and VC funding Healthy Ageing vs Health and total European funding since 2019Dealroom.co.-Data as of Nov 29th 2024.Growth computed comparing funding for 2019-20 with 2023 and pr

32、ojected 2024 value.Source:Healthy Ageing has grown faster than overall VC funding and the rest of Healthtech in the last five years.Page/14 Drug discovery&Therapeutics for age-related diseases is by far the most funded segment.Nutrition&Supplements,Preventative health and Fall&emergency detection sh

33、ow the strongest growth.Top European Healthy Ageing segments by VC funding and growthLongevity Silver HealthDealroom.co-Data as of Nov 29th 2024.Growth computed comparing funding for 2019-20 with 2023 and projected 2024 value.*There are both longevity and silver health digital tools in our mapping.S

34、ource:Page/15 UK Healthy Ageing startups have raised more than the next 4 ranked European Countries.Switzerland has seen the second strongest activity,more than double that of France,Ireland,Germany.Top European countries by VC funding allocated to Healthy Ageing since 2019$1.3BDealroom.co.Data as o

35、f Nov 29th 2024.Source:Page/16 Silver HealthLongevity TechTop investors in European Longevity&Silver HealthDealroom.co.Data as of November 2024.The most active investors have been selected according to the number of rounds in which they invested into companies highlighted in our Healthy ageing lands

36、cape;Excluding Debt,Grants and rounds from Support programs.The list excludes accelerators.Pre-Seed:$0-$4M;Early-Stage:$4-$100M;Late-Stage:$100M+Source:Page/17 1Healthy Ageing2VC Trends3Silver Health4Silver Economy5LongevityPage/18 While life expectancy is rising,time spent in poor health has increa

37、sed by a decade and remains proportionally unchanged,partly due to chronic diseases.Common chronic or non-communicable diseases(NDCs)in older adults include Alzheimers,Parkinsons,other neurodegenerative diseases,rheumatoid arthritis,cardiovascular diseases,macular degeneration,chronic respiratory di

38、seases,cancer,and diabetes.37%of Europeans aged 65 and over have multiple chronic conditions.Chronic diseases account for 9 out of 10 deaths in the EU,and account for an estimated 700B yearly,up to 80%of all healthcare spending in the EU.Cardiovascular disease and cancers alone account for almost tw

39、o thirds of deaths in the EU.5427733719602019Average global life expectancy Average years spent in poor or moderate healthDealroom.co,National Library of Medicine,McKinsey,Our World in data,EfpiaSource:Average global lifespan and share spent in poor health“Chronic pain is highly prevalent among olde

40、r adults where it is associated with significant suffering,disability,social isolation,and greater costs and burden to health care systems.Chronic pain is also a risk factor for premature death and accelerated cognitive decline.Unfortunately,over half of chronic pain sufferers find no relief from cu

41、rrent treatments,primarily pharmaceuticals with side effects that worsen with age.This significantly impacts their quality of life,causing sleep disorders,anxiety,depression,and social isolation.Remedee Labs offers an innovative solution to improve the lives of chronic pain sufferers,especially olde

42、r adults.It combines the first personal endorphin stimulator using millimeter wave therapy with a digital platform,data integration,and personalized coaching.The device is simple and user-friendly,making it ideal for older individuals.Remedee has achieved positive clinical results and CE Medical Mar

43、king(class IIa)approval for relieving osteoarthritis(OA)symptoms,a condition affecting 500 million people globally,73%of whom are aged 55 and older.This solution can enhance quality of life and promote healthier aging.As a strategic partner of Generali,Remedee Labs aims to make its solution accessib

44、le to patients worldwide.”Gilles LitmanCo-founder,Deputy CEO&Chief Business Officer of Remedee LabsPage/20 Projected spending shift from treatment to prevention*Addressing chronic disease through preventive care,early intervention,and better management is key to controlling healthcare costs in Europ

45、e.Preventive health startups in Europe view online83%39%61%17%Treatment&CareWell-being&prevention20192040Dealroom.co,*DeloitteFor more information,refer to the State of Global Insurtech report.Source:“Preventative health applied to ageing is probably the most important and yet underfunded area of He

46、althcare today.A person aged over 75 consumes 25 times more healthcare resources than someone below 65 in France.Chronic conditions prevalence increases exponentially with age so our already strained healthcare systems require a massive shift of focus from treatment towards primary and secondary pre

47、vention to sustain the population ageing burden.Long term partnership between Tech,Insurance and Public health is key.Whilst the promise to live healthily for 100+years drives a lot of investment in elite longevity tech,more investment needs to go towards cost-effective and scalable digital Silver H

48、ealth innovations,both from a solution standpoint but also from Health&Life insurers and healthcare systems to help sponsor,roll-out,educate and train people to use an increasing number of great technologies and tools.AI driven program personalisation,gamification and innovations in behaviour change

49、 applied to lifestyle will help drive massive adoption by the new generation of tech savvy Boomers.Five Lives is happy to count Generali as one of its Partners to foster healthy ageing.”Sylvain PiquetCo-Founder of Five LivesPage/22 VC Funding in digital tools for age-related conditions per launch ye

50、ar cohortsSelect rounds in digital tools for age related conditions view onlineSimilar to the broader digital health funding trend,funding for digital tools targeting age-related conditions peaked in 2021 and has declined since.CompanyRoundDateApplication$125m Late VCOct 2021Neurorehabilitation$100m

51、Series CMay 2021Metabolism$100m ConvertibleJun 2017Sleep 29.2mEarly VCSep 2024Hair loss 1.5mSeedSep 2020Parkinsons2010-2014 2015-2020 2020-2024Dealroom.coData as of Nov 29th 2024.Source:Page/23 By 2050,the EU is projected to have 38.1 million people in need of care,with demand already exceeding the

52、capacity of care workers and facilities.Source:view all onlineImprove nursing homes operations and helping families find the right accommodationProvide professional at-home careConnecting families with trusted self-employed caregiversEnabling community servicesTech tools can reduce inefficiencies an

53、d save time for professional caregivers and structure and empower non-professionals to deliver higher-quality care.However,as a segment,they have only raised$220M in VC funding.Example of startups offering platforms and tools to:Of long-term care in Europe is provided by non-professional carers(fami

54、ly members,neighbors,volunteers etc.)due to the high-cost of care.80%Non-professional caregivers,thats 19x the number of professionals.78MOf care provided annually by non-professional carers,it is valued at 576B(3.63%of Europes GDP).72B hoursDealroom.co *Caritas:Europes care systems at risk,European

55、 Economic and Social Committee:CaregiversSource:Page/24 Despite rising isolation among elders and the wider population,solutions for loneliness see fewer rounds of funding.18%of adults in Europe report being socially isolated(roughly 75 million people).9%pointsmore likelynot to engage often in socia

56、l activities(in adults aged 65 and over,compared to the 26-45-year age group).15 Cigarettes per dayIs what the effects of loneliness on our bodies compares to.Loneliness can increase the risk of depression,cardiovascular diseases,and cognitive impairment.Applications:view 30+Senior Mental Health sta

57、rtupsConnecting to others and younger generationsDigital content(exercise,entertainment etc.)Companion robotsNumber of VC rounds in Senior Mental Health startups$01m(pre-seed)$14m(seed)$415m(series A)$1540m(series B)Dealroom.co,European commission,Brussels TimesData as of Nov 29th 2024.Source:“Aging

58、 well is not just about extending life,but about enriching it for everyone.At Poupette,we are reimagining how families and seniors navigate care,driven by a mission to make aging well accessible to all.Through innovation of service,we deliver personalized,accessible,and human-centered solutions that

59、 improve later life and re-enchant old age.By harnessing cutting-edge technology and pairing it with empathy,we simplify the complexities of elder care while prioritizing quality and trust.Our goal is to empower families with confidence and clarity,offering solutions that truly make a difference in

60、the lives of their loved ones.”Alix GardCo-Founder of PoupettePage/26 1Healthy Ageing2VC Trends3Silver Health 4Silver Economy5LongevityPage/27 As the global population ages,the retirement protection gap(shortfall between needed and actual retirement income)is growing massively.The top need in post-r

61、etirement is to maintain current standard of living.Retirement protection gapKey post-retirement age-well needs*20202050$400T$99T4x1)WEF 2)Capgemini The Aging Well Opportunity,2023Source:Page/28 Dealroom.co EIOPA,CapgeminiThe adoption of savings and life insurance products needs to increase to ensur

62、e quality of life in post-retirement.view all onlineB2B financial advisory software for savings,pension and life insuranceB2C savings,pension,and life insurance platformsEmployee benefits and corporate pensionEnd-of-life planning(Estate and will planning)Example of startups helping the adoption of s

63、avings and life insurance products:of Europeans are financially confident in their retirement,and most EU citizens fully depend on statutory pensions for their future retirement income.Only 45%higher saving rate by Europeans in respect to Americans(13%vs 4%).But Europeans tend not to invest these sa

64、vings in the capital market.3x own a personal pension product.Citizens with a supplementary feel more financially confident in their retirement.Only 19%of 65+consumers have yet to look for professional advice to prepare for retirement and wealth transfer in 2023.60%Source:Page/29 70+startups offerin

65、g financial services for silver economy in Europe Explore the landscapePage/30 “Healthy Ageing sits at the crossroads of a broader set of socio-economic factors interacting with one another,including:healthcare,social isolation,caregivers and financial planning.We are amid historys largest intergene

66、rational wealth transfer,impacting industries across the board.For insurance,this shift will directly affect approximately 40%of the largest life insurers AuM(around$7.8 trillion).These assets,held by policyholders aged 65+,are set to transfer to younger beneficiaries by 2040.This trend is already i

67、n act,and it imposes insurers to face two axes of development:1.Develop comprehensive ageing-well solutions for 65+customers,focusing on health and financial support.2.Build trust to become the preferred partner for financial planning and ageing-well needs,while actively engaging younger beneficiari

68、es.By tackling these areas,insurers can strengthen relationships with both elderly and younger customers,mitigating potential asset outflows.Following our“Lifetime Partner”model,as Generali we strongly believe that success will hinge on offering flexible,personalized solutions that lower adoption ba

69、rriers and enhance customer experience(CX)through technology-driven,value-added services.These services-spanning wellness,telemedicine,taxation,estate planning,and quality-of-life support-will be essential.Partnering with startups can help insurers quickly seize these opportunities and accelerate ti

70、me-to-market.”Filippo Maria StefaniaGroup Open Innovation&VC ManagerPage/31 1Healthy Ageing2VC Trends3Silver Health4Silver Economy5LongevityPage/32 Life expectancy has been flattening in the past 20 years.The race is now on for a breakthrough to add more healthy years of healthy living.Biotech devel

71、opments,in part funded by Silicon Valley billionaires,are aiming to cure ageing-related diseases,while on the premise of slowing down ageing,scientists believe it could it be stopped and reversed one day.The FDA has signaled its recognition of longevity medicines potential and the possibility of add

72、ressing age-related factors as treatable conditions.LBS,Oxford,and Harvard suggested that extending just one healthy year of life is worth$38 trillion to the global economy and extending healthy life by 10 years could net greater than$300 trillion.Life expectancyBy birth yearDealroom.co,The economic

73、 value of targeting agingSource:Page/33 What are the different approaches for slowing down or reversing ageing that are getting funded?Cell repair®enerationRestores or replaces damaged cells and tissues to keep the body functioning optimally.Genetic&epigenetic modificationsAlters genes or their e

74、xpressions to slow down or reverse ageing process.Cellular clean-upImproves the bodys ability to remove damaged cells and proteins.Immunity&inflammationBoosts immune system function and reduce chronic inflammation,which declines with age.Metabolism&dietary$1BCombined funding$690MCombined funding$120

75、MCombined funding$100MCombined funding$12MCombined fundingEnhances cellular energy production,which declines with age.Lifestyle changes can boost overall health.View landscape Dealroom.coSource:Page/34 Explore the Longevity landscape Explore the landscapePage/35 Many billionaires have been funding l

76、ongevity startups.Sergey Brin&Larry Page(Google)Peter Thiel(Paypal)Li Ka-shing(CK Hutchison Holdings)Yuri Milner(Mail.ru)Jeff Bezos(Amazon)Osman Kibar(Genoptix)Brian Armstrong(Coinbase)-InvestmentVitalik Buterin(Etherium)Elon Musk(Tesla)BryanJohnson(Braintree)Jim Mellon(AIM)Christian Angermayer(Apei

77、ron)Sam Altman(Open AI)Page/36 VC funding in longevity startups per regionTop rounds in longevity in the US view onlineUS longevity startups have raised almost 3x more funding than European counterparts in 2024.2022 was a standout year for the US,mainly led by Altos Labs$3B round.Europe US“While you

78、 cant buy youth,you can fund aging research-a field capturing the attention of billionaires and VCs,with over 700 biotech and techbio startups racing to unlock the secrets of longevity.Advances in DNA repair,cellular reprogramming,and telomere elongation are unlocking the mechanisms of life and deat

79、h,with insights from short-lived animal models like C.elegans.Meanwhile,the profound impact of sleep,diet,and exercise underscores the foundational role of lifestyle in extending lifespan.However,Nobel laureate Venki Ramakrishnan warns against oversimplification-turning back the biological clock isn

80、t a simple hack and may disrupt the balance between aging and cancer.For instance,enhancing DNA repair pathways can slow aging but may also increase cancer risks.At Speedinvest,we support ventures addressing these complexities with rigorous science,deep understanding of biological balances and clear

81、 pathways to clinical validation.”Estelle BotbolSenior Associate at SpeedinvestPage/38 Daria GherghelasAssociateAt SpeedinvestEglantine DupuyResearch Associate At Dealroom.coContributorsEstelle BotbolSenior AssociateAt SpeedinvestFilippo Maria StefaniaGroup Open Innovation&VC ManagerAt GeneraliLorenzo ChiavariniResearch LeadAt Dealroom.co