2020年英國制藥行業概述報告 - 愛爾蘭企業署（英文版）（72頁）.pdf

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1、Part of the Evolve UK series The UK Pharmaceutical Sector An Overview Enterprise Ireland is the Irish Governments trade and innovation agency. It invests in the most innovative Irish companies through all stages of their growth and connects them to international customers across multiple industries.

2、 Our goal is to build successful, long-term business relationships between Irish companies and international partners. With offices worldwide, Enterprise Irelands teams of industry experts consult with international businesses to understand and solve their businessneeds. The UK remains the largest e

3、xport market for indigenous Irish Companies. Enterprise Ireland supports Irish companies in the UK from offices in London and Manchester with Market Advisors across a wide array of sectors from construction to digital. Enterprise Ireland has commissioned Shibumi Consulting Limited to provide an over

4、view of the UK pharmaceutical sector. This report was completed in December 2019 and the information was collated using online searches and information available in the Enterprise Ireland Market Research Centre (MRC) at East Point, Dublin. A full list of sources used appears in the Appendix of this

5、report. Contact Laura Brocklebank Senior Market Advisor laura.brocklebankenterprise- +44 161 638 8717 Kevin Fennelly Market Executive kevin.fennellyenterprise- +44 161 638 8716 Enterprise Ireland Lowry House 17 Marble Street Manchester M2 3AW www.enterprise- www.globalambition.ie/evolveuk 1 Enterpri

6、se Ireland UK Pharmaceutical Sector Overview Contents Overview - Facts this is the Pharmaceutical Price Regulation Scheme (PPRS). Heavy R wearable or implantable bio-signs monitors, drug delivery devices with web-enabled dose counters) is expected to result in significant improvements. 10 3. Changin

7、g manufacturing model (CDMOs) As already highlighted, the blockbuster paradigm is predicted to come to an end. This model is all about large scale production for broad use and application. Instead the move is towards more tailored medication and treatment regimen, which means smaller scale, batch pr

8、oduction. The pharmaceutical industry has also seen increased price pressure nationally and globally from generics and the prices negotiated under the pharmaceutical Price Regulation Scheme (PPRS). In addition, due to increasing demands and complexity with regards to manufacturing laws a supplement

9、that has been shown to boost brain function. Headquarters Reckitt Benckiser PLC Turner House103-105 Bath RoadSlough, BerkshireSL1 3UH Telephone +44 (0)1753 217800 Staff40,000 globally UK LocationsTwo UK sites, both in Slough Turnover12.6bn Website 24 Eli Lilly and Company Ltd “Lilly makes medicines

10、that help people live longer, healthier, more active lives.” Treatment Areas Diabetes Treatment of pulmonary arterial hypertension Cancer: lung, gastric, breast Treatment of erectile dysfunction Treatment of depression, Anxiety, Obsessive- compulsive disorder, Bulimia nervosa, Schizophrenia Treatmen

11、t of Attention-Deficit/Hyperactivity Disorder (ADHD) Diabetic peripheral neuropathic pain Migraine Treatment of osteoporosis Treatment of growth retardation Rheumatoid arthritis Psoriasis Stress Urinary Incontinence R&D Treatment Areas Today, we largely concentrate in therapeutic areas in which we h

12、ave deep expertise, including diabetes, neurodegeneration and Alzheimers disease, and oncology, alongside research in therapy areas that build on that expertise and our knowledge of chronic conditions, such as pain and immunology. UK Headquarters Eli Lilly and Company Limited Lilly House, Priestley

13、Road, Basingstoke, Hampshire, RG24 9NL Telephone 01256 315000 Staff33,000 worldwide, 800 staff in the UK, across two sites HQ LocationsIndianapolis, Indiana, U.S.A. Turnover964.3m Websitehttps:/www.lilly.co.uk/ 25 Roche Products Ltd “Founded in 1896, Roche continues to search for better ways to prev

14、ent, diagnose and treat diseases and make a sustainable contribution to society. We have one mission: to do now what patients need next.” “In 2017 Roche invested 388m pounds in UK R&D and conducted 181 clinical trials1 More than 519 million Roche diagnostic tests were carried out, and more than 700,

15、000 people benefited from our medicines in the UK during 20171. We contributed 1.2 billion in UK GDP and supported 16,600 UK jobs” Treatment Areas Anemia Cancer Cardiovascular Disease Central nervous System Dermatology Hepatitis B&C HIV/AIDS Infectious Diseases Inflamatory & Autoimmune Diseases Inte

16、nsive Care Medicine Leukaemia Lymphoma Metabolic Disorders Obesity Ophtalmology Osteoporosis Respiratory Disorders Rheumatoid Arthritis Skin Cancer Transplantation R&D Pipeline Oncology: solid tumours, metastatic cancers, breast cancer, bladder cancer, head & neck cancer, melanoma, ovarian cancer, p

17、ancreatic cancer, leukaemia, prostate cancer, lung cancer Immunology: asthma, autoimmune /inflammatory diseases, food allergy, Crohns disease Ophthalmology: diabetic macular edema, macular degeneration, geographic atrophy Infectious Diseases: Hepatitis, influenza, Metabolic Diseases Neuroscience: Al

18、zheimers, Autism, cognitive impairment, psychiatric disorders, Parkinsons, Huntingtons Headquarters Roche Products Ltd Hexagon Place, Falcon Way, Shire Park, Welwyn Garden City AL7 1TW, United Kingdom Telephone +44 1707 366000 Turnover963.6m Websitehttps:/www.roche.co.uk 26 Pfizer UK “We strive to s

19、et the standard for quality, safety, and value in the discovery, development, and manufacture of medicines and vaccines that have the potential to save lives, prevent illness and improve health and wellbeing. But we dont achieve this alone. Collaborations with healthcare providers, patient communiti

20、es, academia, and policy makers are fundamental to bringing new medicines to patients.” Treatment Areas Anti-Infectives: over 80 anti-infective medicines, antibiotics, anti-fungal, anti-virals Inflammation & Immunology: rheumatoid arthritis, ulcerative colitis Internal medicine: metabolic disease, c

21、ardiovascular disease, diabetes, cachexia, steatohepatitis, fatty liver disease Oncology: cancer treatment Rare diseases: affect 3.5 million people in the UK, only 5% of rare diseases have an available treatment Vaccines: prevent bacterial infections, eg Pneumonia, menegitis R&D Pipeline Anti-Infect

22、ives: Antimicrobial Resistance Inflammation & Immunology: rheumatology, gastroenterology, dermatology, restoration of immune system & tissue health Internal medicine: treatment of metabolic abnormalities, more targeted therapies, control of eating disorder, non-alcoholic fatty liver disease & steato

23、hepatitis Oncology: develop more targeted and sophisticated treatments, rare cancers Rare diseases: advance gene therapy treatments Vaccines: infectious diseases, maternal immunisation, cancer vaccines Pfizer in the UK: https:/youtu.be/J8r9WcM9B14 Headquarters Pfizer UK Walton Oaks, Surrey Telephone

24、 Staff2,500 UK LocationsCambridge, Walton Oaks, Sandwich, Hurley & Havant Turnover850.3m Websitehttps:/www.pfizer.co.uk/ 27 Merck Sharp & Dohme Ltd “Our mission is simple: support our people, collaborate with our partners, do it all for our patients - and continue Inventing for Life.” Treatment Area

25、s Cardiovascular Endocrinology Immunology Infectious diesease Neuroscience Oncology Respiratory Urology Vaccines Womens Health R&D Infectious Disease: HIV, bacterial infection Cardiovascular disease: Heart failure Neuroscience: Shizophrenia Oncology: Melanoma, colorectal cancer, breast, cervical, so

26、lid tumour, biliary tract cancer, gastric, liver, prostate, ovarian, meothelioma, lung, bladder, endometrial, pancreatic Respiratory & Immunology: Neurofibromatosis, Syncytial virus, cough Vaccine: Cytomegalovirus, pneumoconjugate, Ebola UK Headquarters Merck Sharp & Dohme Ltd UK Hertford Rd, Hoddes

27、don EN11 9BU Telephone +44 1992 467272 UK Locations5 Sites: Hoddesdon, London, Milton Keynes, Cramlington, Edinburgh UK Staff2,000 Global HQKenilworth, NJ, USA Turnover748.4m Websitehttps:/www.msd- 28 Bayer PLC “Bayer is a global enterprise with core competencies in the Life Science fields of health

28、 care and agriculture. Its products and services are designed to benefit people and improve their quality of life. “ “In 2018 we invested a total of 5.2 billion in research and development.” Treatment Areas Prescription: Haematology Neurology Oncology Ophthalmology Cardiology Womens health Radiology

29、 Over The Counter: Travel health Womens health Analgesics Digestive health Skincare Nutrition Allergy Foot care R&D Cardiovascular & Kidney Diseases: Chronic Kidney Disease, Thrombosis, Heart Failure, Artery Disease, Diabetes, Renal Anemia Oncology: Cancer, Lymphoma, Prostate Gynecology: Endometrios

30、is, contraception, Fibroids Hemophilia: Gene therapy Others: Acute Respiratory Distress Syndrome, COPD, Cough, Obstructive sleep Apnea, Rheumatoid Arthritis UK Headquarters Bayer PLC 400 S Oak Way, Reading RG2 6AD Telephone +44 118 206 3000 UK LocationsReading & Cambridge Turnover720.4m Websitehttps

31、:/www.bayer.co.uk/ 29 Novartis Pharmaceuticals UK Ltd At Novartis, our focus is on innovating to address the most significant unmet needs of patients and societies in the UK and worldwide. We are harnessing our heritage of advancing medical science to reimagine how we fight disease and how we delive

32、r treatments to the millions of people in the UK who need them. We are Novartis, and we are reimagining medicine. “Since 2014, we have invested over 200 million on research and development in theUK” Treatment Areas Oncology: Advanced breast cancer, Melanoma, Neuroendocrine tumours (NETs), Acute and

33、Chronic Myeloid Leukaemia, Myelofibrosis and Polycythaemia Vera (MPNS), Lung cancer, Renal cell carcinoma, Immune thrombocytopenia Cardiovascular, renal & metabolism Respiratory & Inflammation Immunology, Hepatology & Dermatology Neuroscience: Migraine, MS, Alzheimers, Parkinsons epilepsy, ADHD, Oph

34、thalmic medicines R&D R&D Oncology Cell & Gene Therapy: blood borne cancers, sickle cell disease, thalassaemia, other diseases of the blood Respiratory & Inflammation: COPD, allergic asthma, chronic spontaneous uricaria Dermatology, rheumatology Neuro science: MS, Alzheimers, neuromuscular therapies

35、, human genetics Rare Diseases: TSC, Cushings disease Headquarters Novartis pharmaceuticals UK Ltd 2nd Floor, The WestWorks Building, White City Place, 195 Wood Lane, London, W12 7FQ Telephone +44 1276 692255 Staff1,300 UK LocationsLondon, Surrey, Lincolnshire Turnover631.1m Websitehttps:/www.novart

36、is.co.uk/ 30 Smith & Nephew “Smith+Nephew is a global leading portfolio medical technology business. We care, we collaborate and we have courage as we work to help people live Life Unlimited” Wound Management Reduce the risk of seroma, haematoma, dehiscence and infection after surgery Promote autoly

37、tic debridement Dressings that are effective against over 150 pathogens and can be bactericidal in 30 minutes Prevention of pressure ulcers Joint replacement Hip, knee and shoulder joints as well as ancillary products such as bone cement. Sports Medicine Broad array of instruments, technologies and

38、implants to perform minimally invasive surgery of the joints, including: Repair of soft tissue injuries Degenerative conditions of the knee, hip and shoulder. Ear, Nose, Throat Tonsil and Adenoid Wands Sinus surgery Epistaxis devices Septoplasty and turbinate reduction surgeries Removal of tissue in

39、 surgical procedures of Laryngeal and soft palate anatomy. Headquarters Smith & Nephew Croxley Park, Building 5, Hatters Lane, Watford, Hertfordshire WD18 8YE Telephone Staff16,000 globally UK LocationsWatford & Hull Turnover3.8bn Websitehttps:/www.smith- 31 AAH pharmaceuticals Ltd “A healthier worl

40、d where people can live life to the fullest. Delivering over 15 million items per week to more than 14,000 pharmaceuticalcies and other organisations, AAH is the largest pharmaceutical wholesaler within the UK and operate from 16 modern distribution centres.” Product catalogue https:/www.aah.co.uk/r

41、esource/blob/27926 /5e14c25b7d338033c0b202d3824a8fac/otc- may-catalogue-data.pdf Headquarters AAH pharmaceuticals Ltd Sapphire Court, Walsgrave Triangle, Coventry CV2 2TX Telephone Subsidiary of McKesson Cooperation UK Staff21,000 Locations16 distribution centres - (http:/www.aah.co.uk/shop/en-GB/aa

42、hpoint/locations) Turnover3.4bn Websitehttp:/www.aah.co.uk/ 32 Vertex pharmaceuticals (Europe) ltd “Vertex creates new possibilities in medicine to cure diseases and improve peoples lives. We work with leading researchers, doctors, public health experts and other collaborators who share our vision f

43、or transforming the lives of people with serious diseases, their families and society.” Collaboration Defines Our Culture “Vertex realizes that collaborating with the worlds experts is a cornerstone to solving some of sciences most difficult problems. It defines our culture. Externally, our collabor

44、ations with companies, academia, research organizations and nonprofit organizations help drive scientific innovation and the development of newmedicines.” R&D Pipeline Cystic Fibrosis Pain Hemoglobinopathies: Sickle Cell Disease Antitrypsin Deficiency Kidney Disease Muscular Dystrophy Approved Medic

45、ine Trikafta Symdeko Orkambi Kalydeco All for treatment of cystic fibrosis UK Headquarters Vertex pharmaceuticals (Europe) Ltd 2 Kingdom Street, London, W2 6BD Telephone +44 2032 045100 R&D: Abingdon, Oxon, UK 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW Tel: +44 (0) 545-554-434

46、3 Corporate HQ: Boston, US Turnover1.8bn Website 33 IQVIA UK “IQVIA is a world leader in using data, technology, advanced analytics and human expertise to help customers drive healthcare - and human health - forward. Together with the life sciences and NHS stakeholders we serve, we are enabling a mo

47、re modern, more effective and more efficient healthcare system, and creating breakthrough solutions that transform business and patient outcomes.” IQVIA Joins Landmark UK Health Data Digital Initiative IQVIA will deliver technology and capabilities to support DATA-CAN, the new national Health Data R

48、esearch Hub for Cancer, to improve outcomes for NHS cancer patients. Realising the UKs potential to be a unique Life Sciences centre of excellence 8Ndo&list=PLbAr7MAaEbwOithDcqSWcHVZM RgQpqgTw R&D Solutions in the UK Pavs&list=PLbAr7MAaEbwOithDcqSWcHVZM RgQpqgTw&index=3 UK Headquarters IQVIA UK 210

49、Pentonville Rd, London N1 9JY 1 Quayside, Cambridge CB5 8AB Telephone +44 1223 350553 Bishop Meadow Rd, Loughborough LE11 5RE Telephone +44 20 3075 5000 HeadquartersDanbury, Connecticut, US Turnover1.1bn Website 34 Appendix References Euromonitor country report: pharmaceuticalceuticals in the United Kingdom, November 2018 Euromonitor country report: pharmaceuticalceuticals and Medical Equipment in the United Kingdom, November 201