如何在任何年齡達到最佳表現.pdf

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1、Presented by:2024 Longevity SummitJoseph Maroon,MD,FACSClinical Professor and Vice Chairman of the Department of Neurological SurgeryUniv of Pittsburgh Medical CenterHow to Attain Peak Performance at Any AgeDr.Joseph MaroonLongevity SummitJanuary 26,2024Topics Success,failure,and how a run around a

2、high school track saved my life Stress and the mind/body connection The best antidepressant Peak performance at any ageThe foundation is crackingThe windows are cloudyThe water is leakingThe roof is threadbareHow to Die young As Late As PossibleFirst 15 Years!Day”JobBrain tumorSecond 15 Years“All th

3、ings must suffer,go dark and perish before they can live again”“The life of every man is a diary in which he means to write one story,and writes another;His humblest hour is when he compares the volume as it is with what he vowed to make it.”British author Sir James BarrieMind-Body ConnectionPsychon

4、euroimmunologyWe Need StressStress Neurotransmitter loss DepressionHormone The Secret to a Balanced Life!RelationshipsSpirituality WorkPhysicalSpirituality RelationshipsWorkPhysical“My Square”The“run”that saved my life“Cmon,Joe,”he said.“Itll be good for you.”“Tin Man”TriathlonSwim 1/2 mile,bike 15

5、miles,Run 6.2 miles Increased my BDNFNeuronogenesisSynaptogenesisBrain plasticityEnhanced neurotransmittersSerotoninAcetylcholineDopamineNorepinephrineAnandamideExercise and the BrainLowers stress-induced cortisolRewires the brainRegular physical exercise:The Best Antidepressantand Anxiolytic How th

6、e Body Heals the Brain“Exercise is free,rarely induces side effects and can muffle existing feelings of anxiety and depression,or even prevent their occurrence in the first place.”1993 20031996 2008 1999 20102001 2013Muncie 70.3,2016,2017,2019,2020,2021,2022https:/www.florence- Oxygen-A RenaissanceT

7、BI,Stroke,Aging,Cognition,MemoryLong COVID,Peak PerformanceHBOT More Pressure=More O2 in Blood&Intercellular SpaceGenerally Accepted Uses for HBOTWoundsPrimary TreatmentOthersOncologyhttps:/ skin grafts and flapsNon-HealingTraumaticInfectionsBurnsRadiation tissue damageOsteoradionecrosisRadiosensiti

8、serProphalactically in irradiated tissuesAir or gas embolismDecompression sicknessCarbon Monoxide poisoning and smoke inhalationAcute sensorineural hearing lossIntracranial abscessBells palsyNeurorehabilitation(CP,head injury,stroke,etc.)HBOTHyperbaric Oxygen Therapy Increases Telomere Length and De

9、creases Immunosenescence in Isolated Blood Cells:A Prospective Trial Aging is characterized by the progressive loss of physiological capacity.At the cellular level,two key hallmarks of the aging process include telomere length(TL)shortening and cellular senescence.This the study indicates that HBOT

10、may induce significant senolyticeffects including significantly increasing telomere length and clearance of senescent cells in the aging populations.Senescent cell changes with HBOTHachmo Y,Hadanny A,Abu Hamed,Doenyas Efrati S.Hyperbaric oxygen therapy increases telomere length and decreases immunos

11、enescence in isolated blood cells:a prospective trial.Aging(Albany NY).2020Telomeres and AgingAs cells divide over time telomeres shorten,and eventually cell division stops.Telomeres,end caps thatprotect the chromosomeChromosomeCourtesy of Amir Hadanny,MD,PhD,Sagol Center for Hyperbaric Medicine and

12、 Research,Shamir Medical Center,Israel,Aviv Scientific,LTDYour average telomeres length is presented as a percentage change,comparing them pre and post HBOT:Your total PBMC telomeres lengthened by 100.6%HBOT For Training&PerformanceCan HBOT Boost Athletic Performance?(2022)Effects of hyperbaric oxyg

13、en therapy on mitochondrial respiration and physical performance in middle-aged athletes:a blinded,randomized controlled trialBy two unique processes:1.Increasing the oxygen level in the tissues of the body and brain.2.Fluctuating the level of oxygen to enhance the bodys natural processes of rejuven

14、ation(Increase Mitochondrial Biogenesis)3.Hyperoxic-Hypoxic ParadoxHadanny et al.Sports Medicine-Open(2022)8:22 https:/doi.org/10.1186/s40798-021-00403-wMuscle Biopsy Increased Mitochondrial DensityMuscle staining with MTG demonstrates a significant increase in the mitochondrial mass marker MTG comp

15、ared to the SHAM group(17.12%20.2 vs.8.548.41,p=0.0002).Positive counts are represented by green dots.Greener/brighter images reflect higher counts of MTG stainingHadanny et al.Sports Medicine-Open(2022)8:22 https:/doi.org/10.1186/s40798-021-00403-wSubjective report0102030405060708090100Cognitive ch

16、ange Aerobic fitnesschangeEnergyPost trainingrecoveryGeneralsatisafactionPercent of patientsSHAM(N=11)HBOT(N=15)*=0.001*Hadanny et al.Sports Medicine-Open(2022)8:22 https:/doi.org/10.1186/s40798-021-00403-wChanges in Maximal Cardiopulmonary Exercise Tests CPET Elite(N=13)424446485052545658SHAMHBOTVo

17、2AT/VO2MAX0123456789SHAMHBOTMililiter/Minute*KgVo2MAX/Kg Change*-0.05,MeanSEHadanny et al.Sports Medicine-Open(2022)8:22 https:/doi.org/10.1186/s40798-021-00403-wTreatments:60(3 Months)2 ATA Dives with 100%O2Pre and Post HBOT Assessment Neurocognitive evaluation Memory,attention,information processi

18、ng speed,coordination,planning and reasoning executive function-NeuroTrax,MOCA Anatomical Brain Imaging MRI/DTI with and without contrast(fractional anisotropy)SPECT(single proton emission computerized tomography)Physiological and Blood evaluation Cardiopulmonary(Bruce protocol)and respiratory evalu

19、ation Balance and flexibility Telomeres and ProteomicsPost Treatment Cognitive Assessment Results Improvement in recall Improvement in executive function and cognitive flexibility Mild improvement in attention Mild improvement in information processing speedINFLAMMATIONCancerAlzheimersNeurological d

20、iseasesArthritisCardiovascular diseasesPulmonary diseasesAutoimmunediseasesType IIdiabetesPost CPET Treatment Results(*significant)3%improvement in Lung Capacity(Spirometry)15%improvement in Exercise Endurance(CPET)*10%improvement in Anaerobic Threshold(CPET)*13%improvement in Exercise Power Output(

21、CPET)*29%reduction in fall risk(TUG test)*7%improvement in Muscle Strength(Sit to Stand test)Triathlon Time Before and Post HBOTImprovement of 24 Minutes or 9.2%Time:3:42:15 July 10,2021Swim:36:30TR 1:6:32Bike:1:25:45TR 2:2:49Run:1:30:39Time:3:17:42 September 11,2021Swim:27:08TR 1:7:35Bike:1:15:22TR 2:1:46Run:1:25:51St.Petersburg Triathlon,Aug.2021National Senior Olypmics TriathlonMay 15,2022Chicago TriathlonAugust 2022Thank YouThe Long and the Short of it!Thank Y