張桂紅更新-藍耳病的凈化與經濟效益分析.pdf

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1、S So ou ut th h C Ch hi in na a A Ag gr ri ic cu ul lt tu ur ra al l U Un ni iv ve er rs si it ty y P Pr ro of f.G Gu ui ih ho on ng g Z Zh ha an ng g華華南南農農業業大大學學 張張桂桂紅紅教教授授The eradication of PRRSV and its economics analysis 藍耳病的凈化與經濟效益分析一帶一路國際生豬產業大會OUTLINE 提 綱Surveillance of PRRSV eradication 藍耳病的凈

2、化監測 Economics analysis of PRRSV eradication 凈化經濟效益分析一帶一路國際生豬產業大會Eradication凈化1、Goal of PRRSV control 確定藍耳病的防控目標1.Surveillance of PRRSV eradication 一、藍耳病的凈化監測Control 控制Positive immunized stability(2vx)or positive non immunized stabilityPositive stable low prevalence(1B)Negative with herd closure or r

3、eplacementNegative with depopulation and repopulation 一帶一路國際生豬產業大會過去的分類方法：4類Previous classiffied categories:4PRRS negative farmPRRSV凈化場藍耳陽性穩定場PRRSV postive stable farm藍耳陽性不穩定場PRRSV positve unstable farm藍耳發病場Farm with PRRSV oubreaksAgePCRELISASow母母豬豬POS陽陽POS陽陽Birth出出生生POS陽陽POS陽陽Wean斷斷奶奶POS陽陽POS陽陽AgeP

4、CRELISASow母母豬豬Neg陰陰POS陽陽Birth出出生生Neg陰陰POS陽陽Wean斷斷奶奶POS陽陽POS陽陽AgePCRELISASow母母豬豬Neg陰陰Neg陰陰Birth出出生生Neg陰陰Neg陰陰Wean斷斷奶奶Neg陰陰Neg陰陰AgePCRELISASow母母豬豬Neg陰陰POS陽陽Birth出出生生Neg陰陰POS陽陽Wean斷斷奶奶Neg陰陰POS陽陽陽陽性性不不穩穩定定場場positve unstable farm發發病病場場Outbreaks陽陽性性穩穩定定場場positve unstable farm陰陰性性場場negative farm自己場屬于哪個等級？W

5、hich category does your farm belong to?（2）Understanding PRRSV status 了解豬藍耳病的分類等級-Holtkamp,D.J.et al.Terminology for Classifying Swine Herds by Porcine Reproductive and Respiratory Syndrome Virus Status.J.Swine Health Prod.2011,19,44-56.一帶一路國際生豬產業大會最新的藍耳病感染狀態的劃分方法Latest PRRSV Herd Classification Meth

6、ods-Holtkamp,D.J.;Torremorell,M.;Corzo,C.A.;Linhares,D.C.L.;Almeida,M.N.;Yeske,P.;Polson,D.D.;Becton,L.;Snel,H.Proposed Modifications to Porcine Reproductive and Respiratory Syndrome Virus Herd Classification.J.Swine Health Prod.2021,29,10.現在的分類方法：6類 Current Classification(category standards):6 Cate

7、gories藍耳陽性不穩定場（高流行率）1ACategory-A:Positive unstable;High prevalence 藍耳陽性不穩定場（低流行率）1BCategory-B:Positive unstable;Low prevalence藍耳陽性穩定場（使用疫苗，2vx）Positive stable(immunized with vaccine）藍耳陽性穩定場（不使用疫苗，2）Positive Stable趨于陰性（3）Provisional NegativePRRSV凈化場（4）Negative一帶一路國際生豬產業大會-Holtkamp,D.J.;Torremorell,M.

8、;Corzo,C.A.;Linhares,D.C.L.;Almeida,M.N.;Yeske,P.;Polson,D.D.;Becton,L.;Snel,H.Proposed Modifications to Porcine Reproductive and Respiratory Syndrome Virus Herd Classification.J.Swine Health Prod.2021,29,10.一帶一路國際生豬產業大會統計分析豬場4年的生產數據并與PRRSv等級進行匹配。PRRSv等級不同，生產水平也存在差異。Analyze the production data of th

9、e pig farm for 4 years and match it with the PRRSv level.The production level varies depending on the PRRSv level.生產水平隨著豬場PRRSv等級的提升而提高。The production level increases with the increase of PRRSv level in pig farms.PRRSv等級與繁殖性能相關Correlation of PRRSv Herd Classfication with reproduction parameters*過過渡渡

10、期期：豬豬群群PRRSv爆爆發發后后的的第第11周周至至豬豬群群提提升升到到1B等等級級。*不不同同的的上上角角標標a、b、c代代表表組組間間具具有有統統計計學學差差異異(a=.05)。*SE:PRRSv各各等等級級對對應應生生產產參參數數標標準準誤誤差差（等等級級劃劃分分參參考考美美國國豬豬獸獸醫醫協協會會2.0版版本本）Litter sizePiglets born alive/litterPiglets born loss/litterWeaned Piglets/sowPreweaning mortality Terms/weekPositive unstable High preva

11、lence Positive unstable low prevalence Positive stable Transition Period 一帶一路國際生豬產業大會n以以前前：血血清清或或處處理理液液 Previous samples:serum or processing fluidsnPCR檢檢測測：母母豬豬（流流產產）、出出生生仔仔豬豬（產產房房弱弱仔仔或或斷斷尾尾的的浸浸出出液液）、斷斷奶奶弱弱仔仔豬豬、后后備備豬豬nELISA檢檢測測：母母豬豬（流流產產）、出出生生仔仔豬豬（產產房房弱弱仔仔或或斷斷尾尾浸浸出出液液）、斷斷奶奶弱弱仔仔豬豬、后后備備豬豬PCR and ELISA

12、:Sows(abortion)、newborns(weak piglets or processing fluids),weak weaned piglets,gilts檢測（監測）方法 Surveillance Methods采采樣樣方方法法及及方方案案要要正正確確！且且省省錢錢！1.臨床和生產數據：早期發現疫情 Clinical or production data:early detection2.個體檢測：血清樣本、咽拭子、舌尖滲出液(TTF)Individual sampling:seurm,tonsil,tongue tips fluids(TTF)3.群體檢測：Populatio

13、n-based sampling仔豬處理液(PF)processing fluids家族口腔液(FOF)family oral fluids聲音監測：Sound detector,for example:如Sound Talks空氣采集器 Air detector現現在在now：一帶一路國際生豬產業大會Processing fluids 處處理理液液(PF)Family oral fluids家家族族口口腔腔液液FOFTongue Tips Fluids舌舌尖尖液液TTFOral swabs口口腔腔拭拭子子一帶一路國際生豬產業大會Oral fluids collection 口腔液采集一帶一路

14、國際生豬產業大會Processing fluids collection處理液采集-Courtesy of Iowa State University一帶一路國際生豬產業大會PRRSv的的FOF窩窩陽陽性性時時，針針對對不不同同的的流流行行率率，所所需需樣樣本本采采集集量量(95%置置信信區區間間)Number of FOF sampels based on different PRRSV prevalence rate(95%confidence interval)如如：當當流流行行率率在在3%時時，為為了了至至少少檢測到1份陽性樣品(95%置信區間)，至少采集90份血清樣本或10份家族口腔

15、液樣本。Example:If PRRSV prevalence rate is 3%,at least 90 serum samples or 10 FOF samples are neeed to detect at least 1 postive sample.FOF家家族族口口腔腔液液Prevalence rate(%)Number of serum samplesNumber of FOF samples一帶一路國際生豬產業大會n后后備備豬豬進進群群檢檢測測分分析析說說明明（依依然然可可以以用用血血清清）nInterpretation of detection results from

16、 introduced gilts(serum samples still work)AgePCRELISA說說明明Interpretation備備注注Gilts后后備備Neg陰陰-POS陽陽+沒沒有有帶帶入入新新病病毒毒No new infection最最佳佳 Ideal ConditionNeg陰陰-Neg陰陰-沒沒有有任任何何抵抵抗抗力力No protection新新進進群群后后備備豬豬可可能能被被感感染染導導致致不不穩穩定定Newly introduced gilts might be infected and become unstablePOS陽陽+Neg陰陰-新新病病毒毒進進入入

17、 New infection可可能能導導致致原原來來母母豬豬群群不不穩穩定定might cause sows to become unstable POS陽陽+POS陽陽+新新病病毒毒進進入入New infection可可能能導導致致原原來來母母豬豬群群不不穩穩定定might cause sows to become unstable 一帶一路國際生豬產業大會n 斷斷奶奶弱弱仔仔檢檢測測結結果果釋釋義義（放放養養還還是是一一體體化化？）n I In nt te er rp pr re et ta at ti io on n o of f d de et te ec ct ti io on n

18、r re es su ul lt ts s f fr ro om m w we ea ak k w we ea an ne ed d p pi ig gl le et ts s(t tw wo o s si it te es s o or r f fa ar rr ro ow wi in ng g t to o f fi in ni is sh he er r)日日齡齡AGEPCR檢檢測測ELISA說說明明備備注注斷斷奶奶弱弱仔仔weak weaned pigletsNeg陰陰-POS陽陽+沒沒有有帶帶入入新新病病毒毒 進進入入保保育育舍舍No new infection into nurse

19、ry room多多數數場場狀狀態態，最最佳佳Common cases,Best ScenarioNeg陰陰-Neg陰陰-沒沒有有任任何何抵抵抗抗力力Lack of protection生生物物安安全全好好的的場場最最佳佳！Best result in good biosecurity farms進進入入保保育育舍舍后后可可能能被被感感染染導導致致保保育育豬豬發發病病yet might be infected after entryPOS陽陽+帶帶著著病病毒毒進進入入保保育育舍舍Introduce new infection into nursery room導導致致保保育育舍舍不不穩穩定定母母

20、豬豬問問題題導導致致Causing instability in nursery facilitiesDue to sow problemsPOS陽陽+一帶一路國際生豬產業大會血液：金標準。Blood:gold standard.睪丸處理液(PF)：豬群的一種方法。是一種能夠高效監控數100頭以上5日齡內仔豬的合體樣本。Testicular processing fluid(PF):A method used in pig herds.It is a composite sample that can efficiently monitor over 100 piglets within 5

21、days of age.家族口腔液(FOF）：適用于斷奶期仔豬，反映了斷奶期窩水平PRRSV的活躍度。Family Oral Fluid(FOF):Suitable for weaning piglets,reflecting the activity of PRRSV at the litter level during weaning.口腔液(OF)：適用于斷奶后任意階段豬群，包括母豬和公豬。Oral fluid(OF):Suitable for any stage of post weaning pig herds,including sows and boars.舌尖液(TTF)：最近

22、研究?？勺鳛檫m用于任何階段死亡豬只的目標樣本。Tongue tip fluid(TTF):Recent research.Can be used as a target sample for dead pigs at any stage.臍帶？Umbilical cord?咽拭子：公豬？Swab:A boar?一帶一路國際生豬產業大會右右側側圖圖引引自自豬豬疾疾病病報報告告系系統統，該該系系統統收收集集并并統統計計了了美美國國5個個獸獸醫醫診診斷斷實實驗驗室室（愛愛荷荷華華、明明尼尼蘇蘇達達、南南達達科科他他州州、堪堪薩薩斯斯州州和和俄俄亥亥俄俄州州)的的診診斷斷數數據據。The figure

23、 on the right is from the Pig Disease Reporting System,which collects and compiles diagnostic data from five veterinary diagnostic laboratories in the United States(Iowa,Minnesota,South Dakota,Kansas,and Ohio).2008年年口口腔腔液液樣樣本本出出現現前前，血血清清樣樣本本（約約50%）和和組組織織樣樣本本(38%)占占主主導導。Before the appearance of oral

24、fluid samples in 2008,serum samples(about 50%)and tissue samples(38%)were dominant.2012年年：逐逐漸漸出出現現可可替替代代樣樣品品類類型型，包包括括口口腔腔液液和和血血拭拭子子。In 2012,alternative sample types gradually emerged,including oral fluids and blood swabs.2017年年：處處理理液液(PF)出出現現，并并且且迅迅速速成成為為主主導導的的樣樣本本類類型型（63%）。In 2017,processing fluid(

25、PF)emerged and quickly became the dominant sample type(63%).Evolution of sample types for PRRSV detectionPRRSV檢檢測測樣樣本本的的演演變變表表明明：Indicating:血血清清和和口口腔腔液液(OF)仍仍被被用用于于：Serum and oral fluid(OF)are still used for:確確認認斷斷奶奶階階段段仔仔豬豬的的PRRSv狀狀態態Confirm the PRRSv status of piglets during the weaning stage進進行行測

26、測序序Perform sequencing當當考考慮慮到到所所有有豬豬群群階階段段時時，口口腔腔液液依依然然是是占占主主導導的的樣樣本本類類型型?？诳谇磺灰阂航浗洺３Ｓ糜糜谟诒O監控控生生長長-育育肥肥和和后后備備豬豬豬豬的的PRRSv狀狀態態。When considering all stages of the pig population,oral fluid remains the dominant sample type.Oral fluid is often used to monitor the PRRSv status of grow-fattening pigs and gilt

27、s.一帶一路國際生豬產業大會n豬豬場場高高度度生生物物安安全全措措施施：包包括括空空氣氣過過濾濾、清清群群、部部分分清清群群、消消毒毒等等。nH Hi ig gh h l le ev ve el l b bi io os sa af fe et ty y m me ea as su ur re es s f fo or r p pi ig g f fa ar rm ms s i in nc cl lu ud de e a ai ir r f fi il lt tr ra at ti io on n,h he er rd d c cl le ea an ni in ng g,p pa ar rt

28、 ti ia al l h he er rd d c cl le ea an ni in ng g,d di is si in nf fe ec ct ti io on n,e et tc c.n疫疫苗苗免免疫疫：經經典典毒毒株株、變變異異株株、活活苗苗/滅滅活活苗苗？nV Va ac cc ci in ne e i im mm mu un ni it ty y:c cl la as ss si ic ca al l s st tr ra ai in ns s,m mu ut ta an nt t s st tr ra ai in ns s,l li iv ve e/i in na ac ct

29、 ti iv va at te ed d v va ac cc ci in ne es s?n血血清清人人工工馴馴化化：后后備備豬豬nA Ar rt ti if fi ic ci ia al l d do om me es st ti ic ca at ti io on n o of f s se er ru um m:g gi il lt ts sn藍藍耳耳病病封封群群凈凈化化：抗抗原原、抗抗體體雙雙陰陰性性nP PR RR RS SV V c cl lo os su ur re e e er ra ad di ic ca at ti io on n:A An nt ti ig ge en

30、n a an nd d A An nt ti ib bo od dy y D Do ou ub bl le e N Ne eg ga at ti iv ve en飼飼養養管管理理新新模模式式：多多點點飼飼養養？（A AS SF FV V后后一一體體化化）、分分胎胎次次飼飼養養nN Ne ew w m mo od de e o of f f fe ee ed di in ng g m ma an na ag ge em me en nt t:m mu ul lt ti i-p po oi in nt t f fe ee ed di in ng g?(I In nt te eg gr ra at

31、te ed d a af ft te er r A AS SF FV V),d di iv vi id de ed d p pa ar ri it ty y f fe ee ed di in ng gn公公豬豬精精液液nB Bo oa ar r s se em me en nn中中藥藥、抗抗藍藍耳耳病病毒毒的的藥藥物物、抗抗生生素素等等控控制制病病毒毒增增殖殖復復制制或或繼繼發發感感染染nT Tr ra ad di it ti io on na al l C Ch hi in ne es se e m me ed di ic ci in ne e,a an nt ti i b bl lu ue

32、 e e ea ar r v vi ir ru us s d dr ru ug gs s,a an nt ti ib bi io ot ti ic cs s,e et tc c.c co on nt tr ro ol l v vi ir ru us s p pr ro ol li if fe er ra at ti io on n,r re ep pl li ic ca at ti io on n,o or r s se ec co on nd da ar ry y i in nf fe ec ct ti io on nn后后備備豬豬！nR Re es se er rv ve e p pi i

33、g g!n豬豬流流的的管管理理！nM Ma an na ag ge em me en nt t o of f P Pi ig g F Fl lo ow w!n個個性性化化方方案案：一一場場一一策策！Personalized protocol:One farm,one program!3、藍藍耳耳病病的的綜綜合合防防控控方方案案Comprehensive PPRSV prevention and control protocols一帶一路國際生豬產業大會基因變異：血清型（PRRSV-1，PRRSV-2），亞型多Genetic variation:serotypes(PRRSV-1,PRRSV-2

34、),multiple subtypes感染宿主譜窄（豬），體內外細胞偏嗜強，豬肺泡巨噬細胞(PAM)；Limited host range(in pigs),strong cell tropsim in vivo and in vitro,porcine alveolar macrophages(PAMs);感染PAMs，損傷免疫系統，導致炎性因子風暴；Infection in PAMs causes damage to the immune system,leading to an inflammatory cytokine storm;免疫抑制，豬體天然免疫和獲得性免疫弱；Immune s

35、uppression,weak innnate and acquired immunity in pigs;病毒抗體依賴增強作用(ADE)，非中和抗體和低水平中和抗體促進病毒逃逸；Virus antibody dependent enhancer(ADE),non neutralizing antibodies and low-level neutralizing antibodies promote virus escape;病毒持續感染，引起長時間病毒血癥(4w)；Persistent infection causing prolonged viremia(4W);亞臨床感染豬扁桃體和淋巴

36、結持續帶毒排毒數月。Subclinical infections in pig tonsils and lymph nodes,harboring and shedding virus for several months.病原的生物學特性 Biology of PRRSVPRRSV可可以以自自清清除除！凈凈化化的的理理論論依依據據！PRRSV can clear itself!The theoretical basis for eradication!一帶一路國際生豬產業大會豬場藍耳病管理的核心點Key points in PRRS management 選址：Site selection:

37、盡量減少后備豬進群次數（自循環）：6個月或更長時間閉群管理檢測隔離，免疫馴化Minimize the number of gilts introduction(slef replacement):close the herd for 6 months or longer,vaccination and acclimatation控制豬場內部豬群流動管理：Manage the pig flow within the farm:分點生產？，全進全出，分胎次、批次化生產：multiple site system?,All in and all out,parity segregation and b

38、atch farrowing:免疫管理：疫苗選擇及免疫程序（不穩定時連續2次免疫+免疫后8周內所生仔豬需轉出）Vaccination Management:Vaccine Selection and Immunization Program(2 consecutive immunizations in unstable conditions+piglets born within 8 weeks after immunization need to be transferred out)后備豬血清或疫苗馴化：Gilts serum innoculation or vaccine acclima

39、tation:生物安全：清群+部分清群，控制寄養，病弱豬處理，針頭管理等Biosafety:depopu+partial depopu,minimize cross-fostering,managing sick and weak pigs,needle management,etc空氣過濾？Air filtration?實驗室監測：系統的采樣方案和跟進檢測計劃Laboratory monitoring:comprehensive sampling plan and follow-up surveillance抗生素或中藥等Antibiotics or traditional Chinese

40、medicine,etc一帶一路國際生豬產業大會二二、藍藍耳耳病病凈凈化化效效益益分分析析 Economics analysis of PRRS eradication一部法律；A law;六個指導意見：綠色發展、現代種業、農業轉型升級、畜牧業高質量發展、生豬產業持續健康發展、疫病凈化工作Six guiding opinions:green development,modern seed industry,agricultural transformation and upgrading,high-quality development of animal husbandry,sustaina

41、ble and healthy development of pig industry,and disease eradication project若干計劃方案、技術指南、技術規范Several planning schemes,technical guidelines,and technical specifications國家對疾病凈化的政策支撐National policy support for disease eradication一帶一路國際生豬產業大會但能維持多久？凈化后維持1.6年以上具有效益 But how long can it last?The effort is fi

42、nanciallly justified only if farms can be maintained negative for at least 1.6 years after eradication.周邊環境 Surrounding environment空氣過濾？Air filtration?現場管理？On site management藍藍耳耳病病的的控控制制及及凈凈化化方方法法是是成成熟熟的的。難難！如如何何預預防防藍藍耳耳病病病病毒毒的的再再次次感感染染是是困困難難的的！The control and eradication methods for PRRS are well e

43、stablished.Difficult!How to prevent the reinfection of PPRSV is difficult!一帶一路國際生豬產業大會生生產產獸獸醫醫和和獸獸醫醫總總監監的的責責任任就就是是要要最最大大程程度度地地降降低低疾疾病病經經濟濟影影響響！The responsibility of production veterinarians and veterinary directors is to minimize the economic impact of diseases to the greatest extent possible!n群群體體生

44、生產產條條件件下下，不不僅僅僅僅是是治治病病、不不死死豬豬。Under population production conditions,it is not just about controlling diseases and keeping pigs alive.n多多數數情情況況下下是是基基于于經經濟濟影影響響分分析析從從而而做做出出控控制制決決策策。In most cases,control decisions are made based on economic impact analysis.n獸獸醫醫要要學學會會與與生生產產溝溝通通！Veterinarians need to l

45、earn how to communicate with production team!n獸獸醫醫要要懂懂一一些些財財務務知知識識！Veterinarians need to understand some financial knowledge!n獸獸醫醫要要懂懂生生產產管管理理！Veterinarians need to understand production management!一帶一路國際生豬產業大會序號疾病頭均增益（元）利潤（元/頭）成本(元/頭)飼料資產折舊人工獸藥疫苗其他業務費用種豬折舊 健康空間 13.8327.1220.021.021.0503.112.01藍耳147

46、.69.2138.589.513310.518.00.66.52副豬嗜血、鏈球菌45.44.640.926.1 4.28.2 2.43巴氏波氏46.80.146.741.03.3 0.8 1.64支原體26.3 26.314.9 9.8 1.65回腸炎23.1 23.114.9 8.2 6PED22.4 22.422.4 7大腸桿菌-梭菌13.6 13.604.44.24.9 8APP（傳胸）11.2 11.211.2 9非瘟4.1 4.10 2.1 2.0 10其他 10疑難雜癥29 0.50 合計369.5 用“錢”說話！Economic returns from disease cont

47、rol or eradication(Muyuan data)-引引自自牧牧原原三三十十年年開開放放日日一帶一路國際生豬產業大會疫苗免疫：活疫苗(不同毒株)、活疫苗+滅活疫苗？Vaccine Immunization:live vaccine(different strains),live vaccine+inactivated vaccine強調“做好”免疫：免疫與做好免疫 Emphasizing doing well:Immunization and doing well in Immunization血清馴化：Serum Acclimatation凈化實施方案：疫苗免疫與血清馴化效益分析

48、Eradicaiton Implementation Plan:Analysis of the Benefits of Vaccine Immunization and Serum Acclimatation一帶一路國際生豬產業大會安安全全性性和和免免疫疫原原性性都都很很重重要要，需需要要一一個個最最好好的的平平衡衡點點!Safety and efficacy are both important and require the best balance!疫苗毒株來源遺傳分類 部分廠家CH-1R中國經典毒株人工致弱譜系8維科、海利、普萊柯、大北農、易邦、天邦、乾元浩、華派Ingelvac ML

49、V美國經典毒株VR2332毒株人工致弱譜系5勃林格R98中國經典自然弱毒株（與VR2332高度同源）譜系5瑞普、中岸、東方帝維JXA1-R中國高致病性變異毒株人工致弱譜系8大華農、普萊柯、瑞普、天邦、國藥HuN4-F112中國高致病性變異毒株人工致弱譜系8正業、維科、海利GD-r180中國高致病性變異毒株人工致弱譜系8永順、信得TJM-F92中國高致病性變異毒株人工致弱，自然基因缺失譜系8碩騰、天康、特研、華威特、隆克爾PC嵌合疫苗、自然弱毒譜系8金宇，國藥等一帶一路國際生豬產業大會疫苗毒株來源廠家抗原含量純度佐劑CH-1a中國經典毒株滅活疫苗佑本3ug/ml4%Uplus復合佐劑CH-1a中

50、國經典毒株滅活疫苗美保龍 108.0TCID50/ml 無數據自噬小體M-2中國流行毒株滅活疫苗國藥 108.0TCID50/ml 11%復合雙向佐劑一帶一路國際生豬產業大會后備豬血清馴化Serum acclimatation in gilts 自家血清：200-500個病毒粒子（活病毒）Autogenous serum:200-500 virus particles(live virus)自制標準曲線：ct值與TCID50的關系 Self made standard curve:relationship between ct value and TCID50一帶一路國際生豬產業大會2種種穩穩

51、定定母母豬豬群群的的藍藍耳耳活活毒毒暴暴露露方方法法的的恢恢復復穩穩定定時時間間及及疾疾病病損損失失比比較較Comparison of Recovery Stability Time and Disease Loss of Two Stable PRRS Live virus Exposure Methods for Sow Herds一帶一路國際生豬產業大會目標監測指標標準TTBP回到基準生產水平Back to baseline-斷奶前仔豬死亡率；Pre-weaning mortality-母豬繁殖性能指標；sow reproduction performance產房成活率及母豬繁殖性能恢復

52、到暴發前水平；pre-weaning mortality and sow reproduction performance reach baseline productivity before the outbreakTTNP（TTS）生產陰性仔豬Produce negative piglets-仔豬睪丸液的抗原檢測；PRRSV PCR with processing fluids-斷奶仔豬血清的抗原檢測；PRRSV PCR with piglet serum-斷奶日齡的仔豬間隔4周檢測1次，連續4次（連續90天）保持陰性；detection once every 4 weeks with w

53、eaned piglets;remain negative for 4 consecutive samplings(90 days)一帶一路國際生豬產業大會母豬群發生PRRS后，用弱毒苗控制比用全群野毒接種控制，總體經濟損失更小。After the occurrence of PRRS in sow herds,the overall economic losses are smaller using live vaccine for control than using whole herd exposure with live virus inoculation使用疫苗，TTBP更短一些：

54、可以更快的恢復到基準生產水平；With vaccines,TTBP is shorter:it can recover to baseline production levels faster;使用血清，TTNP更短一些：可以更快的生產陰性仔豬；With serum,TTNP is shorter:it can produce negative piglets faster;(DCL linhares et al.2018)一帶一路國際生豬產業大會如果用弱毒苗免疫，能快速恢復到正常生產水平（合格周斷奶仔豬數），但是要生產出陰性斷奶仔豬需要的時間長If immunized with a live

55、 vaccine,it can quickly recover to normal production levels(number of qualified weaned piglets per week),but it takes a long time to produce negative weaned piglets如果使用血清感染，恢復到正常生產水平需要的時間長，但是能快速生產陰性斷奶仔豬If serum innoculation used,it takes a long time to recover to normal production levels,but it can

56、quickly produce negative weaned pigs一帶一路國際生豬產業大會一帶一路國際生豬產業大會結結果果發發現現類類NADC30毒毒株株CHsx1401置置換換HP-PRRSV毒毒株株JXwn06的的Nsp2后后會會刺刺激激更更強強的的免免疫疫反反應應（炎炎癥癥反反應應），病病毒毒血血癥癥會會更更快快地地被被清清除除、組組織織中中的的病病毒毒載載量量也也相相對對最最低低，The replacement of Nsp2 of the NADC30 like strain CHsx1401 with the HP-PRRSV strain JXwn06 stimulated

57、 a stronger immune response(inflammatory response),resulting in faster clearance of viremia and relatively lower viral load in the tissue,反反之之類類NADC30毒毒株株的的nsp2誘誘導導免免疫疫反反應應（炎炎癥癥反反應應）的的能能力力相相比比HP-PRRSV更更弱弱，可可以以不不被被機機體體的的免免疫疫反反應應識識別別，更更為為“狡狡猾猾”地地隱隱藏藏起起來來In contrast,the ability of nsp2 of the NADC30 st

58、rain to induce immune response(inflammatory response)is weaker compared to HP-PRRSV,and it can hide more cunningly without being recognized by the bodys immune response（sneaky nature）NADC30毒毒株株更更難難控控制制一帶一路國際生豬產業大會 影響多生、少死、長得快的相關指標：基于某階段的豬價及飼料價格 Parameters about more births,fewer deaths,and faster gr

59、owth:based on pig and feed prices at a certain stage 窩產均健仔影響：每增加1頭，影響全程成本0.06元/斤 Average litter size:for every additional newborn,reduce the whole course cost by 0.12 RMB/Kg 分娩率影響：分娩率每提高1%，影響全程成本0.003元/斤 Farrowing rate:for every 1%increase,reduce the whole course cost by 0.006 RMB/Kg 哺乳仔豬成活率影響：每提高1%

60、，影響全程成本0.015元/斤 Preweaning mortality:for every 1%decrease,reduce the whole course cost by 0.03 RMB/Kg 斷奶均重影響：每增加0.01KG，影響全程成本0.02元/斤 Average weaned weight:for every 0.01KG increase,reduce the whole course cost by 0.04 RMB/Kg 空懷母豬比例：每提高1%，影響全程成本0.01元/斤 The proportion of open sows:for every 1%decrease

61、,reduce the whole course cost by 0.02 RMB/Kg 出欄成活率：成活率每上升1%，全程斤成本下降0.025元/斤 Finalized Survival rate:For every 1%increase,reduce the whole course cost by 0.05 RMB/Kg 日增重、料肉比、飼料轉化率等 Daily weight gain,feed to gain ratio,feed conversion rate,etcEffect of PPRSV on Production KPI主主要要生生產產效效率率指指標標影影響響簡簡單單測測

62、算算：一帶一路國際生豬產業大會母豬死亡率：假如每月0.3%-0.8%，每降0.1%死亡，肉豬成本下降0.01元/斤(按母豬存值4000元計)Mortality rate for sows:If 0.3%-0.8%per month,for every 0.1%decrease in mortality,finisher cost will decrease by 0.02 RMB/kg(calculated based on the stock value of sows at 4,000 RMB)母豬淘汰率：假如目前正常淘汰率月3.5%左右，40%-60%/年更新率，月降1%，則每斤肉豬成本

63、下降0.06元(按每頭母豬淘汰虧損3000元計)Sow culling rate:If the current culling rate is around 3.5%per month,with an annual renewal rate of 40%-60%,and a monthly decrease of 1%,finisher cost will decrease by 0.12 RMB/kg(calculated as a loss of 3,000 RMB per culled sow)簡簡單單測測算算：Effect of PPRSV on Production KPI主主要要生

64、生產產效效率率指指標標影影響響一帶一路國際生豬產業大會疾病發生時，不僅影響豬群的采食量，而且豬只會動用一部分能量來啟動機體的免疫系統，從而抵抗病原菌，造成料肉比升高。When diseases occur,not only does it affect the feed intake of pig herds,but pigs only use a portion of their energy to activate the bodys immune system,thereby resisting pathogens and causing an increase in the feed

65、to meat ratio.如果料肉比降低0.1-0.2，每斤肉豬成本可降0.16-0.32元。If the feed to meat ratio is reduced by 0.1-0.2,finisher cost will decrease by 0.32-0.64 RMB/kg(Currently 45-90 RMB)簡簡單單測測算算：Effect of PPRSV on Production KPI主主要要生生產產效效率率指指標標影影響響一帶一路國際生豬產業大會動物的日增重；The daily weight gain of animals;飼料轉化率；Feed conversion

66、rate;存活率（直至出欄）；Survival rate(until slaughter);胴體率；Carcass percentage;治療：獸藥Treatment:veterinary medicine 豬豬藍藍耳耳病病毒毒（PRRSv）感感 染染對對生生長長育育肥肥豬豬的的不不同同生生產產指指標標的的影影響響范范圍圍，其其中中平平均均日日增增重重的的減減緩緩范范圍圍從從 2%至至 40%不不等等；飼飼料料轉轉化化率率的的下下 降降范范圍圍從從 1.7%至至 37%不不等等；而而死死亡亡率率的的增增加加范范圍圍從從 1%至至 15%不不等等。The impact of PRRSv infe

67、ction on different production indicators of growing and fattening pigs varies from case by case,average daily weight gain reduced by 2%to 40%;feed conversion rate reduced by 1.7%to 37%;mortality increaed by 1%to 15%.豬豬藍藍耳耳病病經經濟濟影影響響的的 5 年年分分析析中中，藍藍耳耳陰陰性性（未未感感染染 PRRSv）豬豬有有 96.4%以以原原價價格格銷銷售售，但但這這一一數數據

68、據對對于于藍藍耳耳陽陽性性（感感染染 PRRSv）豬豬將將下下降降 到到 95.7%。In the 5-year follow-up analysis of the economic impact of PRRSV,96.4%of PRRSV negative pigs were sold at the original price,but this number decreased to 95.7%for PRRSv infected pigs.一帶一路國際生豬產業大會研究對2014-2017年暴發的4次PRRS疫情進行了成本和收入的計算：The study calculated the c

69、osts and revenues of the four PRRS outbreaks from 2014 to 2017:結果表明：The results indicate that:每頭母豬增加的損失平均約822.75元（668.14-1004.43元）；The average increase in losses per sow is about 822.75 Yuan(668.14-1004.43 Yuan);肥豬含保育，平攤至每頭母豬，增加損失平均約601.62元（318.64-937.14元）Fat pigs,including nursery pigs,are evenly p

70、rojected to each sow,resulting in an average increase in losses of approximately 601.62 Yuan(318.64-937.14 Yuan)PRRS暴發后帶來的經濟損失平攤到每頭母豬身上合計約1424.37元。The economic losses caused by the outbreak of PRRS were evenly allocated among sows,totaling approximately 1424.37 Yuan per sow.此外還可減少的斷奶仔豬數和降低飼料轉化率是最主要的

71、損失來源。In addition,reducing the number of weaned piglets and decreasing feed conversion rate are the main sources of loss.一帶一路國際生豬產業大會場場次次疫疫病病暴暴發發一一場場F Fa ar rm m 1 1 w wi it th h P PR RR RS SV V o ou ut tb br re ea ak ks s疫疫病病暴暴發發二二場場F Fa ar rm m 1 1 w wi it th h P PP PR RS SV V o ou ut tb br re ea a

72、k ks s藍藍耳耳穩穩定定場場P PR RR RS SV V S St ta ab bl le e f fa ar rm m 藍藍耳耳凈凈化化場場P PR RR RS SV V n ne eg ga at ti iv ve e f fa ar rm m收收益益/批批次次-1 19 9.5 54 4萬萬元元2 20 0.0 08 8萬萬元元2 26 68 8.4 41 1萬萬元元3 34 43 3萬萬不不同同豬豬場場1 13 3批批次次內內平平均均批批次次收收益益A Av ve er ra ag ge e b ba at tc ch h r re ev ve en nu ue e w wi i

73、t th hi in n 1 13 3 b ba ac ct tc ch he es s f fr ro om m d di if ff fe er re en nt t f fa ar rm ms s 以以上上分分析析結結果果顯顯示示了了藍藍耳耳爆爆發發豬豬場場和和未未發發病病豬豬場場的的顯顯著著差差距距，充充分分證證明明了了豬豬繁繁殖殖與與呼呼吸吸綜綜合合征征給給豬豬場場帶帶來來的的巨巨大大經經濟濟損損失失。T Th he e a ab bo ov ve e a an na al ly ys si is s s sh ho ow w a a s si ig gn ni if fi ic c

74、a an nt t d di if ff fe er re en nc ce e b be et tw we ee en n P PR RR RS SV V o ou ut tb br re ea ak k f fa ar rm ms s a an nd d u un na af ff fe ec ct te ed d f fa ar rm ms s,d de em mo on ns st tr ra at ti in ng g t th he e h hu ug ge e e ec co on no om mi ic c l lo os ss se es s c ca au us se ed

75、 d b by y P PR RR RS SV V t to o p pi ig g f fa ar rm ms s.某某集集團團不不同同豬豬場場不不同同藍藍耳耳感感染染狀狀態態經經濟濟效效益益分分析析E Ec co on no om mi ic c A An na al ly ys si is s o of f D Di if ff fe er re en nt t P PR RR RS SV V s st ta at tu us s i in n a a P Pi ig g F Fa ar rm m一帶一路國際生豬產業大會藍耳病凈化前后效益分析Economic Analysis of a

76、sow farm before and after PRRSV eradication-引引自自某某集集團團2 20 02 22 2年年分分享享數數據據指標Parmaters藍耳感染期 PRRSV positve 藍耳凈化后PRRSV negative生產提高Improvement經濟效益（元）Economic benefits返情數（頭/周）Returns(head/week)7.44.33.1頭/周1434.71流產數（頭/周）Aborted(head/week)3.93.70.2頭/周123.42空懷數（頭/周）Empty(head/week)7.32.84.5頭/周3471.07死亡數

77、（頭/周）Death(head/week)5.95.9落地損失（每窩）Farrowing loss(per litter)12.2%8.7%215.25斷奶前死亡數（每批次）Preweaning mortality(per batch)10.1%10.4%一帶一路國際生豬產業大會-引引自自新新豬豬派派調調研研為為什什么么盈盈利利？一帶一路國際生豬產業大會30-100kg一帶一路國際生豬產業大會藍耳感染期，下游育肥成本為18.39元/公斤，藍耳病凈化后，下游育肥成本為15.87元/公斤，一頭標豬 (120公斤)，出欄成本降低302元/頭豬。During PRRSV infection,the d

78、ownstream fattening cost is 18.39 Yuan/kg.After the eradication of PRRSV,the downstream fattening cost is 15.87 yuan/kg.For one pig weighing 120 kg,the market pig cost is reduced by 302 RMB/pig.-引引自自某某集集團團2 20 02 22 2年年分分享享數數據據藍耳病凈化前后效益分析Economic Analysis of a sow farm before and after PRRSV eradica

79、tion一帶一路國際生豬產業大會藍耳病的凈化要有信心！The eradication of PRRSV requires confidence!科普利信、河南民望、神農、加大等公司已維持多年!Coplixin,Henan Minwang,Shennong,Jiada and other companies have been maintaining PRRSV negative for many years!-引引自自新新豬豬派派一帶一路國際生豬產業大會n“Our doubts are traitors and make us lose the good we oft might win by fearing to attempt”.n疑疑惑惑是是一一種種背背叛叛，使使我我們們遇遇事事畏畏縮縮，輸輸掉掉本本可可贏贏得得的的好好與與善善。重重學學習習！懂懂改改變變！強強執執行行！Keep learning!Embrace Innovation!Focus on execution!一帶一路國際生豬產業大會敬敬請請批批評評指指正正！一帶一路國際生豬產業大會