韓后&amp用戶說：2025年中國茶科技嫩膚白皮書（110頁）.pdf

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1、f1?去?匱?送?繃?.?去?撰?嵴嵴?歷?硼歷?歷?歷?.?太?去?導?務?+?-?銳?研?銳?EGCG?撰?籽?去?紙?務?17?繃?務?繃?務?2025?5?9?研?研?研?bilibili?研1?N=1144?研2?嵴?EGCG?N=229?研?研?研?2023/4/1-2025/3/31?研?研?研?匱?6?務?務?/?封?溶?去?研?紙銳?硼?務?務?務?務?務?務?務?映?確?烯?務?EGCG?撰?紙?撰?務?嵴?研?嵴?研?嵴?映?務?封?洲?-?撐?撰?EGCG?紙?去?(?)?701?12?1502?目錄CONTENTS?17?22?25?28?33?39EGCG?撰?63

2、03?04?EGCG?80?撰?91?96?+?102?103?106?9901?12?1.1?1.1.1?2024?Nature?盟?Rakus?Fibraurea tinctoria?1?撰?2?1.1?Nature?君?1.2 Rakus?Fibraurea tinctoria?封?副?務?務?去?務?務?務?撰?粉?3?4-5?13?6?+?4-6?油?油?巨去溶?3?7?1.3?1.4?1.5?1.6?1.7?1.8?1.1.2?務?撰?粉粉?去?500?務?90?7?封?去?撰?14?封?去?-?撰?撰?-EGCGEGCG?撰?EGCG?務NADPH-?P450?9,10,11?撰

3、?65%?撰?務?8?撐?贈?務?去?撐+?銳?去?EGCGEGCG?9090%?副?撐?-?-?撰?12?EGCG?撐?去?銳?銳-?銳?銳?硼?贈?贈?1.9?15?1.10 2025.03MAT?&?研?|?|?研?2025.03MAT?2024?4?2025?3?712712.8 8?134134.8 8%?務?UGC?務封?208208.2 2%?712.8?134.8%83.4%?24.8w38.0%?/?36.4w65.8%讓?讓?/?88.3w?TOP3?/?UGC?64.3%UGC?+208.2%+208.2%?務?16?/?爽?爽?/?1.2?1.2.1?/?16?研?|?

4、|?研?2025.03MAT?2024?4?2025?3?籽?去?讓?/?/?芳務?1.2.2?C?繃?務?映?撰?讓?讓?/?/?1?2?3?4?5?1.11 2025.03MAT?TOP5?171.3?1.3.1?送?封?撰?1.13?&?2.3%8.9%4.3%18.6%59.4%6.6%?務?79.2%20.8%?1.12?8.8%6.2%32.4%22.4%12.3%8.8%9.0%?2020-2425-2930-3435-3940-44?45?N=1144?副?8686.9 9%?務5252.9 9%?紙銳?1.14?&?78.7%21.3%?7.8%5.6%35.8%23.2%1

5、2.1%6.6%8.9%?2020-2425-2930-3435-3940-44?45?研?N=1144?2025?4?181.3.2?69.0%57.1%55.8%53.2%51.7%50.0%48.3%?封?務?銳?銳?映?封?3030-3434?副?封?4.3%12.9%18.4%32.0%16.3%11.4%4.7%?2020-2425-2930-3435-3940-44?45?1.15?1.16?1.3.3?銳?務?務?封?研?研?6464.4 4%?溶?務?務?研?溶?硼?銳?撐?研?N=1144?2025?4?1970.3%57.6%55.3%44.2%?/?/?/?63.2%5

6、9.5%51.3%49.7%46.4%?39.9%24.5%21.8%13.8%?務?務?1.17?1.18?1.19?1.3.4?夠?太?封?太?38.4%?務?37.5%?35.2%?送?籽?研?N=1144?2025?4?20?1.20?1.21?1.22?26.6%?送?65.5%?58.6%?34.9%?63.6%?51.0%?37.5%35.2%28.7%27.6%27.3%24.0%23.4%22.7%?65.5%58.6%46.7%44.8%33.0%?63.6%51.0%49.0%43.8%?1.3.5?研?去?硼?34.2%?送?/?封?紙?副?副?研?N=1144?202

7、5?4?21?研?N=1144?2025?4?副?32.4%32.4%?送?34.2%34.2%?/?56.2%?50.9%?42.7%?56.2%?50.9%?42.7%?57.9%?49.7%?埋31.5%?55.9%?44.4%?42.2%?1.23?TOP2?221.4?1.4.1?研?N=1144?2025?4?53%53%?嵴?48.2%?嵴?銳?聊?聊?47%47%?嵴?34.3%?嵴?1.4.2?導?研?6161.3 3%?嵴?嵴?/?66.3%?/?59.9%?3636.9 9%?嵴?嵴?導?導?贈?繃?告?去?紙?去?61.3%61.1%55.1%?贈?31.5%31.4%

8、31.0%?1.24?1.25?36.9%36.2%33.4%?贈?嵴?粉?1.26?231.4.4?57.4%51.5%48.8%?撰?嵴?1.28?封?贈?務?銳爽?籽?撐?撰?撐?撰?51.5%?副?研?N=1144?2025?4?1.27?贈?務?撰?嵴?嵴?撐?告?嵴?嵴?導?聊?4242.2 2%?痰?嵴?痰?嵴?1.4.3?嵴?告?68.3%?導?49.2%?導?44.0%?贈?43.9%?痰?嵴42.2%24?研?N=1144?2025?4?1.29?48.8%45.6%44.7%44.7%38.9%38.5%?銳爽?嵴?封?紙銳確?撰?A?裂?銳?模?溶?44.7%?嵴?嵴?

9、紙?封?對?副?副?1.4.5?58.6%43.6%31.1%30.7%26.9%?聊?1.30?聊?撰?務?嵴?嵴?紙?嵴?嵴?251.5?務?封?務?務?去?撰?EGCG?撰?EGCG?硼?/?C C?712712.8 8?UGC?6464.3 3%?458?208208.2 2%?+83.4%?讓?/?+65.8%?/?+38.0%?/?撰?務?8686.9 9%?封?封?導?導?告?告?導?嵴?聊?撰?撰?53%?02?2.1?2.1.1?睹?導?銳?告?繃?撐練?夾?副?銳?銳?告T?模?熊?副?T?副?銳?T?嵴?裂?T?歲太?繃?痰?告?熊?野?痰?模?熊?熊?副?籽?熊?裂+?

10、+?撐?包?聊?銳紙?封?28?2.1.2?NMFNMF?務?NMF?癬?NMF?務?NMF?務?12-13?贈?告?烯?贈?群?FA?SFA?務?務?埋?13-14?務?封?包?包?包?VS?撰?務?太?29302.1.3?封?痰?務?痰?去?封?封?封?去?封?去?封?副?撰?烯?封?312.1.3?撐?撰?撰?封?封?MC1R?贈?贈?封?烯?贈?銳?痰?封?裂?裂?太?T?種?去?封?封?太?T?烯?封?映?讓?讓?撰?32?烯?烯?副?烯?粉?烯?務?UVA/UVB?群?群?贈?太?烯?驟?驟?撐?去?烯?紙?撰?銳?332.2?2.2.1?去?序號2013年衰老標識2023衰老標識

11、2025衰老標識1基因組不穩定性基因組不穩定性基因組不穩定性2端粒磨損端粒磨損端粒磨損3表觀遺傳改變表觀遺傳改變表觀遺傳改變4蛋白質穩態喪失蛋白質穩態喪失蛋白質穩態喪失5營養感知失調營養感知失調營養感知失調6線粒體功能障礙線粒體功能障礙線粒體功能障礙7細胞衰老細胞衰老細胞衰老8干細胞耗竭干細胞耗竭干細胞耗竭9細胞間通訊改變細胞間通訊改變細胞間通訊改變10巨自噬功能障礙巨自噬功能障礙11慢性炎癥慢性炎癥12菌群失調菌群失調13細胞外基質改變14心理-社會隔離?2.1?14?15?2.2?2013?-2025?15,16,17?Guido Kroemer?Carlos Lpez-Otn?2025?

12、Cell?封?銳?,?銳-?撐?,?14?去?撐?撐?銳?銳?嵴?嵴?聊聊?34?2.2.2?ageingClinics,?1.8?撰?去?撰?18?epidermisepidermis?dermisdermis?hypodermishypodermis?愿2.3?glabrous skin?太?hair-bearing skin?19?2.3?35?撐?副?撰?繃?95%?Stratum Basale?痰?封?Stratum Germinativum?Stratum Spinosum?Stratum Granulosum?Stratum Lucidum?Stratum Corneum?愿?2

13、.4?19?務封?MelanocytesMelanocytes?melanin?6%?8%?務?20?LangerhansLangerhans CellsCells?3%?6%?20?MerkelMerkel CellsCells?副?務?繃?封?務20?2.4?Clinics,36?務?務?Papillary Dermis?Reticular Dermis?愿?2.5?-?副?Dermal Papillae?務?20-21?:?CollagenCollagen FibersFibers?Fibroblasts?I?III?紙?20?ElasticElastic FibersFibers?撐?

14、20?ReticularReticular FibersFibers?Thin Collagen?Fibronectin?20?ExtracellularExtracellular Matrix,Matrix,ECMECM?18?2.5?Clinics,?372.2.3?2.6?1?A-?SASPSASP?:?:?B-?:?姿?撐練?銳?愿2.6?銳?撰?研?38?2.7?2?C-?:?:MC1R?ASIP?MC1R?ASIP?:ROS-?ROS?(?)D-?:?E-?:?:?君-?君-?導?:?39?2.3?2.3.1?副?銳?溶?銳?務?紙?副?撐練?研?確?務?去?撐?睹?封?聊?繃?2

15、.3.2?封?2.3.3-2.3.6?撰?紙?2.8?紙?包?去?副?DNA?402.3.2?撐?撐?ROS?封?贈導?撐?副?SASP?SASPSASP?aging related secretion phenotype?SASP?SASP?封紙?紙?SASP?務?IL-1?SASP?IL-6?NFNF-BB?SASPSASP?務?務?愿?愿?2 2.1010?愿?愿?2 2.1111?22NFNF-BB?Nuclear?FactorNuclear?Factor-kappa?Bkappa?B?NF-B?務?導?務?NFNF-BB?贈?撰?贈?撰?NF-B?贈?2.9?41SASPSASP?S

16、ASPSASP?IL-1?IL-1?IL-6?IL-7?IL-13?IL-15?IL-18?TNF-?CCL-17?CCL-20?CXCL-1?CXCL-2?IL-8/CXCL-8?IP-10/CXCL-10?IGFBP?EGF?VEGF?PDGF?HGF?BLC?B?COX-1?COX-2?MIF?MMPs?PGE2?ROS?SPARC?2.10?SASP?封?TNF-?贈?NF-B?SASP?VEGF?IL-1?IL-6?TNF-?導?贈導?ROSROS?SASPSASP?撰?撰?去?去?包?包?23,24,25?SASPSASP?IL-1?IL-6?IL-8?IGFBP7?IL-1?IL

17、-1?IL-6?IL-8?TNF-?MMP-1?MMP-2?MMP-3?IL-1?IL-6?HMGB1?MMPs?2.11?SASP?42?ROS?硼?ATP?ROS?DNA?封?封?DNADNA?ROS?ROS贈?NF-B?IL-6?TNF-?贈ROS?-?擦?撐?撐?22-26?封?務?IL-1?封?導?27?繃?SASPSASP?DNA?導?DDR?贈?SASP?IL-6?MMPs?的?MMPs?的?包?太?撐24,25,28?2.13?2.12?君?432.3.3?紙?包?紙?包?撰?痰?贈?贈痰?痰?封?痰?銳?去?去?痰?包?NMF?導?痰?2.14?2.15?44?Desmoso

18、mal Enzymes?Desmosomes?模?詞?TEWL?繃?50%29?銳?烯?模?撰?模?贈?30?詞?告?TEWLTEWL?副?副?31-32?1?Transepidermal Water?Loss,?TEWL?封?TEWL?導?TEWL?2.16?姿?29,31,32?45?模?太?紙?包?洲?愿?2.17?紙?2?包31managementfunctionhttps?封?包?profilaggrin?NMFNMF?NMF?NMF?烯?封?33?NMF?pHpH?烯?務?贈?務?粉?corneodesmosomes?癬包?導?烯?烯?31,32,33?32regional?env

19、ironment?on?the?skin?properties?and?the?early?wrinkles?in?young?Chinese?women.and?Technology,?2.17?2.18?Natural Moisturizing Factor,NMF?務?愿2.18?NMF?pH?烯?pH4.5-5.5?NMF?封?導?46?2.19?50%?副?Aquaporins,?AQPs?副?AQP?AQP?Ceramide?包?TEWLTEWL?愿2.19?Aquaporin?34?癬?-?27,34,35,36?47?GAG?ECM?務?HA?烯?IL-6?TNF-?去?AQP

20、?/?/?FA?贈?HA?副?2.20?33,34,37,38?CHOL?繃?太?銳?模?HAHA?HA?ECM?務?HA?烯?溶?烯?IL-1?包?HA?14-37?+?48?ROS?導?DNA?導?贈?SASP?撐?2.21?君?22,23,24,25,27?3?贈?封?1.?贈?導?2.DNA?封?SASP?撐?3.?ROS?-?撐?-?49?贈?封?銳務?裂?裂?贈?撰?AQP3?EGCG?告?聊?埋?Ceramide NP/EOP?Cholesterol?千?撐?1?銳務?EGCG?B5?嵴?EGCG?嵴?ROS?EGCG?SASP?-?2?50?2.22?2.3.4?去?1?2?2

21、.23?包?映?贈?溶?務?撰?4?1.?歲太?溶?2.?贈?痰?歲太?51?1?副?ROS?2.26?2.24?2.25?繃?送?TYR?千?務?封?1?MC1R?19?MC1R贈?副?39?封?封?ROS?IL-1?TNF-?24?40?1?TYR?模?確?銳紙?ROSROS?去?去?告?52?務?DNA?務?封?封?封?導?導?ROSROS?26?ROS?DNADNA?DNA?DNADNA24?DNA撐?撰?痰群?群?贈導?贈導?ROS?DNADNA?贈?贈?DNADNA?導?23?ROS?DNA?SASP?贈?ROS?2.27 DNA?2?DNA?3?iNOS?封?41?撰?務?贈?封

22、?B?贈?撰?撰?贈?贈?痰?iNOSiNOS?iNOS?2.28?53?封?務?39?MC1R?MC1R?務?繃?MC1R?烯?烯?DNA?撐?撐?MC1R?ASIP?ASIP?MC1R?繃?ASIP?MC1R?42-43?烯?贈?4?2.29 MC1R?MC1R?ASIP?MC1RMC1R?MC1R?1?-MSH?贈?19?ASIPASIP?ASIP?-MSH?MC1R?-MSH?ASIP?副?MC1R?pheomelanin?19?54?2.30?痰?導?2 2?務?務ROSROS?2020S S?紙銳?務?聊研?銳?痰?導?務?導?封?導?導?44?副?-?務?痰千?NH3+?銳?44

23、?ROS?紙?45?副?46?47?48?封?49?55?2?副?10?4?銳?痰?3?嵴?裂?贈?裂?撐?嵴?裂?4?C?E?41-50?撰?銳?銳?1?埋?驟?驟?送?562.3.5?2.31?導撐?導撐?/?務?太?51?1?2?封?羥?副?副?撰?去?52?聊研?53?硼?撰?痰?副?封?紙?導撐?紙?太?撐?贈?銳?2.32?2.34?2.33?57?1?2?務?MMPs?24?務?NMF?33?太?太?19?太?MMPsMMPs?Matrix Metalloproteinases,MMPs?ECM?務?撰?務?MMPs?撐?MMPs?ECM?繃?撐?務?I I?IIIIII?I?8

24、0%-90%?III?太?撰?務?I I?烯?IIIIII?19?烯?烯?20-28?副?MMPs?撰MMP-1?MMP-3?I?24-54?2.35?58I?AGEs?2.37?58,59,60?導撐?2.36?3?AGEs?痰?務?AGEs?RAGE?封?導?贈?ROS?55,56,57?59?紙?贈?I?III?MMPs?A?務?ROS?EGCG?告?導撐?紙?封?嵴?繃?模?2.38?/?/?.?烯?的?.602.3.6?研?務?61?務?撰?副?62?映?撰?副?務?63?/?.?1 1.?2 2.?3 3.?/?撰?愿?2.39?2.39?61-64?61?-?紙?紙?1.?mRN

25、A?65?2.?3?DEJ?3.?去?-?紙?66?務?67?紙?+?2.40?68,69,70,71?贈?封?贈?TLR4?封?副?MMP-1/3/9?-?紙?去?贈?封?導?EOS?-?紙?62?撐?+?贈?MMP?+?贈I?PARP?撐?贈?聊研?2?1?紙?繃?1.?撐?撐?埋?繃?贈?嵴?2.贈?贈?MMP-1/3?埋?撰?撐?EGCG?嵴?嵴?痰?贈I?3.?銳?DNA?繃贈?撐?PARP?EGCG?4-6?DNA?君?君?/?-?-?紙?紙?種?孫?姿?姿?君?姿?63?撐?2.4.1?撐?2.42 EGCG?74AMPK?E3?EGCG贈?AMPK?贈?AMPK?ULK1?映?

26、銳mTOR?EGCG?mTOR?mTOR?PINK1?贈?Parkin?E3?EGCG?贈?PINK1?Parkin?PINK1?Parkin?2.4EGCG?撰?務?務?(+)-?(-)-?(-)-?(-)-?(-)-?EGCG?72?EGCG?A?B?D?廢?C?副?撰?EGCG?B?D?副?痰?封?導?痰?痰?ROSROS?贈?贈?EGCG?ATP?撐?73?2.41?EGCG?73EGCG?痰?ROS?贈?撐?ATP?64EGCG?ROS?2.43 ROS?導?EGCG?79EGCG?ROS?贈?75?EGCGEGCG?ROSROS?贈?贈?ROSROS?贈?贈?NF-B?AP-1?M

27、APKs?贈?贈?導?MMPs?76,77,78?贈?贈?贈導?ROS?EGCG?ROSEGCG?贈?贈?NF-B?AP-1?MAPKs?2.44 ROS?導?EGCG?79ROS?MMPs?Collagenase?Elastase?EGCGEGCG?65EGCG?EGCG?副?TGM-1?HAS-1?HAS-2?2.45 EGCG?導?83?NMF?MMPs?TIMPs?DNA?2.46 EGCG?導?84EGCG?MMPs?80,81,82?EGCG?副?filaggrin?-1?TGM-1?HAS-1?HAS-2?EGCGEGCG?NMFNMF?83?EGCGEGCG?MMPsMMPs?

28、TIMPsTIMPs?EGCG?UV?MMP-1?TIMPs?EGCG?贈?84?撰?紙?EGCG?80100?Jia,?Y.,?Mao,?Q.,?Yang,?J.,?Du,?N.,?Zhu,?Y.,?&?Min,?W.?(2023).?(EpigallocatechinInduced?Photoaging.?Clinical,?cosmetic?and?investigational?dermatology,?16,?14966EGCG?MAPK/ERK?MMP-1?2.4.2?2.48 MAPK/ERK?NF-B?EGCGEGCG?MAPK/ERKMAPK/ERK?85-86?TNF-?贈

29、?ERK?MMP-1?MMP-1?務?模?贈?痰?導?撰?EGCGEGCG?TNFTNF-?ERKERK?贈?贈?MMPMMP-1 1?COICOI-1 1?87?EGCG?10?20M?TNF-?贈?Hs68?務MMP-1?88?ERK?ERK?副?88?EGCG?JNK?p38?贈?告?ERK?88?EGCG?務?贈?EGCG?MAPK/ERK?TNF-?ERK?贈?MMP-1?COI-1?2.47 EGCG?88?IL-7R?CD28?CD40L?CD40?TCR?CD28?CD3?FcR?TLR4?CD14?SYK?LYN?JAK?TAK1?TBK?Dvl?PI3K?AKT?MEK1/

30、2?ERK1/2?JNK?STAT1/2/3?-catenin?NF-kB?TRIF?MyD88?DAP12?Gsk3?Axin?APC?CK1?NICD去?去?Glycolysis/Lactate?Cell?survival?Proliferation?Inflammation?EMT?67EGCG?B?UVB?封?撐練?導?HO?封?贈導?贈導?DNA?封?89?EGCGEGCG?UVB?贈?務?ERK?JNK?p38?贈?90?贈?EGCGEGCG?JNKJNK?贈?贈?導?導?UVB?封?務?EGCG?91?EGCGEGCG?ROSROS?88?91111(2006).?(+)inhi

31、bition?of?JNK?phosphorylation.?Life?sciences,?79(8),?801https:/doi.org/10.1016/j.lfs.2006.02.028EGCG?紙?UVB?HO?JNK?贈?JNK?UVB?務?2.49 EGCG?91050100Control11020AC050100150-+-11020THF-(20mg/mL)EGCG(M)EGCG(M)DPPH?(%)?ROS?(%)(a)(b)?2.50?EGCG?DPPH?(a)?EGCG?Hs68?ROS?(b)8868?2.4.3?DNA?EGCG?紙?ROSROS?92?贈?EGCG?

32、ROS?贈?贈?EGCG?CAT?SOD1?SOD2?GPx?ROS?封?EGCG?SODSOD?93?EGCG?MDA?94?封?2.51 EGCG?ROS?EGCG?Nature?CellDeath&Disease?練?副?Keshav Singh?封?DNA?撐?封?封?DNA?DNA?封?詞?-H2AX?DNA?導?DNA?封-H2AX?EGCG?撐?務?DNA?模?DNA?撐?繃?EGCG?務?撰?紙?ROSROS?贈?贈?NFNF-BB?封?導?導?EGCG?MITF?MC1R?69?研?*?導?EGCG?繃?95?EGCG?導?2%?EGCG?銳?導?10%?EGCG?模?EGC

33、G?NFNF-BB?贈?贈?COX-2?iNOS?務?務?EGCG?撰?GTP?撰?務?EGCG?ECG?愿?2.52?GTP?銳?務?58%?愿?2.53?EGCG?95?GTP?UVB?務?280-315nm?UVA?315-400nm?UVB?GTPGTP?嵴?嵴?2.53?GTP?君?DNA?君?Sunburn?cellsSunburn?cellsLangerhans?cells*Langerhans?cells*DNA?damageDNA?damageVehicle?alone0.1?0.1589?46250?29GTP?alone0.1?0.1569?38262?31Vehicle

34、?+?2?MED?solar?simulated?radiation5.8?0.788?291582?162GTP?+?2?MED?solar?simulated?radiation1.9?0.3?68%?377?28?58%?846?132?55%?Erythema?Index024681012UVVehicleGTP?5%?EGCEGCGECECG?2.52 GTP?2-MED?導?70EGCG?TYR?96-97?務?98?EGCG?MC1R?1?MITF?繃?84?2.54 EGCG?MC1RMITF?副?TYR?EGCG?撐?DNA?EGCG?HACAT?DNA?99-100?-H2

35、AX送?DNA?-H2AX?DNA?HACAT?EGCG?-H H2 2AXAX?HACAT?51.7%?1.6%?EGCG?HACAT?EGCG?BE-EGCG?HACAT?9.1%?2.1%99?EGCG?-H2AX?HACAT?撐DNA?2.55 EGCG?DNA?君?71UVB?NF-B?1012.4.4?EGCG?紙?繃?NF-B?贈?導?NF-B?IB?務?UVB?贈?IB?封?IB?NF-B?NF-B?封?NF-B?EGCG?IBIB?NFNF-BB?-1?IL-1?-8?IL-8?-?TNF-?-2/9?MMP-2/9?2.56 NF-B?君?IB?EGCG?紙?務?贈?務NF

36、NF-BB?MAPKMAPK?務封?務?油?映?詞?SASP?封?SASP?ILIL-6 6?TNFTNF-?EGCG?NF-B?IB?務?UVB?贈?NF-B?IB?NF-B?IB?NF-B?IL-1?IL-8?TNF-?MMP-2/9?72?MAPK?102?撐練紙?務?MAPK?研?EGCG?贈?MAPK?撰?撰?EGCG?贈?ERK?JNK?p38?務?EGCG?封?務ERK?JNK?p38?IL-6?TNF-?mRNA?ELISA?務?HaCaT?贈?EGCG?銳?JNK?p38?副?務PGE?IL-6?TNF-?PGE?IL-6?TNF-?務封?贈?導?PGE太?的?EGCG?MA

37、PK?2.57 MAPK?EGCG?EGCG?MAPK?ERK?JNK?p38贈?導?映?MAPK?贈?ERK?JNK?p38贈?IL-6?TNF-?PGE?73?群?撰?撐練?試?溶?撰?告?痰?C?103?撰?EGCG?紙?EGCG?-贈?-?紙?撐?VC?4545%?25ppm?撰?撰?4040%?2020%?EGCG?2020%?撰?撰?2727%?10ppm?EGCG?1010%?EGCG?撰?撰?4040%?1515%?EGCG?贈?EGCG?副?撐?硼?去?撐?撐EGCGEGCG?C?撰?撰?2.4.5?EGCG?vs?C?2.58 EGCG?EGCGEGCG?VCVC74?C?

38、EGCG?C?EGCG?C?C C4545%?撰?EGCG?繃?務EGCG?89.2%?24?EGCG?EGCG?6 6?副?副?EGCG?24h?8989.3232ug/cmug/cm?EGCGEGCG?1414.7171ug/cmug/cm?撐?DNADNA?HaCaT?ROS?102.2%?152.3%?EGCG?EGCG?3.77?4.31?熊?熊?C?Control?+?C?0.3mg/ml?1?EGCG?1?10mg/ml?13?10mg/ml?-H2AXDAPIOverlay?2.59 EGCGvs?C?DNA?君?-H2AX?EGCG?vs?C?撰?EGCG?EGCG?嵴?EG

39、CG?封?EGCG?務?EGCG?80%?2020%+?EGCG?贈?I?III?IV?8?EGCG?8?撰?贈?撐?EGCG?EGCG?愿?2.60?嵴?EGCG?=?-5?-1?20ppm?副?EGCG?20%?愿?2.61?EGCG?-5?-1?10%?20%?EGCG?vs?2.60 EGCGvs?vs?75050100150200250Control10?ppm20?ppmEGCG?-1?-5COL-I?%?20%20%?10%10%?EGCG?務?EGCG?2 2.9393?3 3.4747?1 1.9595?副?EGCG?EGCG?2 2.4545?EGCG?EGCG?-?EGC

40、G?1.?紙?2.?-?EGCGEGCG?2.62 EGCG?EGCG?詞?2.63?76020406080100120Control20?ppm100?ppm200?ppmEGCG?-1?-5?2.61?EGCGvs?vs?%?10%10%?20%20%?撰?嵴?EGCG?EGCG?EGCG?導?務?0204060801001200.04%0.02%0.01%0.005%0.0025%EGCG?020406080100120Control20?ppm100?ppm200?ppmEGCG?1.?EGCG?EGCG?撰?100ppm?EGCG?8383%?撰?8585%?25ppm?EGCG?6

41、 6%?EGCG?vs?2.64?EGCGvs?DPPH?2.65 EGCGvs?77DPPH?%?85%85%?83%83%?6%6%?%?40%40%?20%20%?20%20%2.?EGCG?撰?2020%?撰?4040%?050100150200250Control10?ppm20?ppmEGCG?1.?I I?EGCG?撰?20ppm?副?EGCG?2020%?撰?2727%?2.?EGCG?撰?IL-1?EGCG?1515%?撰?4040%?2.66?EGCGvs?2.67 EGCGvs?vs?78COL-I?%?27%27%?20%20%?20%20%05010015020025

42、0ControlLPS?50?ppm100?ppmEGCG?IL-6?%?050100150200250ControlLPS?50?ppm100?ppmEGCG?IL-1?%?30%30%?15%15%?03?80?紙?紙?嵴?銳爽?撰?嵴?紙?封?撰?紙?務?撰?LVLV?搓?嵴?搓?嵴?2023?模?嵴?嵴?3.1.1?3.1?EGCG?務?銳務?銳?撰?務?務?務?務?務?3700+種茶葉20+種護膚用茶?10大科研單位200+位科研人員?嵴?1717?嵴?嵴?嵴?嵴?模?1 1.?嵴?嵴?務?務?務?務?務?務?務?務?務?紙?嵴?繃?務?嵴?嵴?1?81?2?太?太?硼?嵴?81?2

43、 2.?封?嵴?封?嵴?EGCG?EGCG?太?太?82?嵴?嵴?17?EGCGEGCG?模?姿?癬?太?3?8080?溶?溶?3535?4545?務?務?務NPCANPCA?EGCGEGCG?NPCANPCA?撰?撰?封?83?4545?溶?銳?溶?銳3535?封?封?4?鋒?鋒?DNADNA?EGCG?務?熊?EGCGEGCG?告?務?務?EGCGEGCG?撐練?撐練?告?8080%?務?EGCG?嵴?撰?EGCG?務?封?贈?ROSROS?副?副?DNADNA?84?EGCG?1?NPCA?EGCG?EGCGEGCG?封撰?EGCG?&?1.?EGCGEGCG?撐?撐?EGCGEGCG?

44、2020?EGCGEGCG?DNADNA?撐?撐?副?EGCGEGCG?溶?務?溶?務?EGCGEGCG?告?告?EGCGEGCG?3.1.2?EGCG?85?&?EGCG?1務?EGCG?嵴?EGCG?1 1?嵴務?嵴務?EGCGEGCG?務?1 1?EGCGEGCG?1務?EGCGEGCG?(?)?(nm)?(%)?(%)EGCG?1083.4-89.2-182.11.4688.11.18281.12.6686.43.14380.23.7785.44.31?(nm)?(nm)?EGCG?183.480.83.08?&?研?EGCGEGCG?EGCGEGCG?HaCaT?ROS?1h1h4h

45、4h8h8h24h24hEGCG?14.3115.6828.1289.32EGCG?0.452.613.1814.71?ROSROS?ROSROS?(%)(%)EGCG?1102.2EGCG?124.2?EGCG?1?EGCG?VC?1?EGCG?VC?EGCGEGCG?VCVC?1?銳?EGCG?1務?EGCGEGCG?銳?銳?EGCGEGCG?0.3mg/ml?1?EGCG?EGCG?1?10mg/ml?EGCG?10mg/ml?86?DNADNA?撐?撐?DNADNA?DNADNA?-H H2 2AXAX?導?導?DNADNA?撐?撐?DNA?務?1?EGCG?C?DNA?撐(-H2AX

46、?)?(?)?DNA?EGCG?1?EGCG?銳?VC?DNADNA?撐?撐?VCVC?1?銳?EGCG?1 1務?務?EGCGEGCG?DNADNA?撐?銳?撐?銳?EGCGEGCG?Control?+?C?0.3mg/ml?EGCG?1?10mg/ml?EGCG?10mg/ml?-H2AXDAPIOverlay2.?模?EGCG?EGCGEGCG?搓?副?導?導?搓?EGCG?EGCGEGCG?ROSROS?務?EGCGEGCG?EGCG?痰?務封?EGCG?/?EGCG?87?ROS?DNA?ATP?1,4-?搓?導?搓?導?EGCG?1?H2O2?DNADNA?撐?撐?撐?撐?銳?銳?

47、EGCGEGCG?1?EGCGEGCG?11?3.1 DNA?君?3.2 ATP?姿?2?EGCGEGCG?太?NPCANPCA?副?副?副?副?1.?封?撰?撰?4 4-?紙?務?副?務導?務?封?NPCA?姿?嵴?嵴?撰?撰?ATPATP?(nM)nM)ATP?ATP?(%(%?)?(?)?1?GSH?0.34698.5760.5413.46?2?-?-?LLA?0.28480.9149.1641.54?3?-2?GAAASP?0.30586.8953.6428.54?4SS?CADLP?0.27377.7847.5446.26?10(EGCG?)-0.14240.4623.4842.56

48、?Control(-L)-0.351-63.1510.54UV?Control(+L)-0.0339.418.89103.488ATPATP?&?務?撰?撰?嵴?1-4務?撰?GSHGSH?-?-?LLA?-2?GAAASP?SS?CADLP?1 1?嵴?務?務ATPATP?0.346nM?撐?撐?9898.5757%?務JC-1?JCJC-1 1?封?1 1務?2.?危?PGA?危?PMPC?危?危?危?ECGG?EGCGEGCG?EGCGEGCG?危?危?務?務EGCGEGCG?封?封?姿?893.1.2?5000?讓?5000?5000?10?聊研?/?研?封?銳?銳?封?EGCG?撰?

49、9 9?撰?聊?撰?聊?20?EGCG?9?撰?90?贈?-9 9?IIIIIV?埋III?I I?撰?撰?10?7?80%80%?NPCA?913.2.1?28?研3.2?28?-12.46%12.46%?-10.86%10.86%?-16.30%16.30%?-17.34%17.34%?-29.56%29.56%?-18.76%18.76%?-17.50%17.50%?-18.80%18.80%?-12.46%12.46%?-12.46%12.46%?-12.46%12.46%?28?-4.22%4.22%?-76.66%76.66%?-74.51%74.51%?+52.34%+52.34

50、%?+17.58%+17.58%?+16.63%+16.63%?&?28?+11.27%+11.27%?+4.25%+4.25%?+21.87%+21.87%?+4.51%+4.51%?+9.66%+9.66%?+31.09%+31.09%?封?封?3.2.2?導?副?229?5?9797%?1 1?痰?痰2 2?副?副?研?送?覆?研?研導?9 9?副?嵴?導?副?嵴?導?5?撰?撰?撰?20?20-24?25-29?30-34?35-39?40-44?45?副?務?3.3?3.4?3.5?92?9356%54%45%31%17%?3.6?9 9?副?副?嵴?嵴?導?導?導?導?l97%97

51、%?痰?l94%94%?痰?l94%94%?痰?l93%93%?痰?53%53%?47%47%?42%42%?34%34%?30%30%?21%21%?8%8%?46%46%?74%74%?28%28%?55%55%?94?37%37%?32%32%?22%22%?54%54%?46%46%?44%44%?導?49%49%?42%42%?27%27%?62%62%?59%59%?95?2828?研務?封?嵴?讓?撰?1?撰?撰?粉?1520?野?聊研?睹?副?1212?1520?模?睹種?510?撰?睹種?2?嵴?嵴?&?銳?;?(TEWL)?粉?/?+?裂?(?A?裂?)+?+?+?A?+?

52、&?繃?粉?+?讓?+?+?+?讓?3.2.3?96?去?銳?銳?贈務?銳?銳?銳?務?務封?粉?2010?盡?IFF?模?封?盟?愿3.7?IFF?封?Myo-relax?研?銳?研104?IberchemIberchem?WavemotionWavemotion?銳?銳?封?導?封?導?痰?痰?副?銳?銳?銳?銳?銳?銳?2025?務?銳-?3.7?副?620.7?710.4?2024.03MAT2025.03MAT?3.8?同比擴張14%25.1?44.7?2024.03MAT2025.03MAT同比擴張78%?3.9?+?3.3?研?研?2023?4?2025?3?3.3.1?去?97

53、研?研?2025.03MAT?爽?的?14%?務?封?嵴?嵴?嵴?嵴?嵴?爽?務?研?爽?封?2024.03MAT?2025.03MAT?15%?2025.03MAT?78%?1?封?確?研?硼?封?銳?銳?銳?銳?紙?紙AIAI?嵴?嵴?嵴?嵴?硼?務?1.?繃?繃?2.?嵴?封?1.?2.?封?1.?2.?嵴?1.副?2.務?去?封?1.?撰?務?封?2.務?務?封?1.副?研?2.務?去?嵴?98?2?務?務?嵴?務?務?&?嵴?1.?2.?100?AI?)3.?35?28?35?劇?1.?SCI?2.務?務?撰?讓?讓?研?研?撰?撰?99?ESGESG?篩?篩?務?務?篩?硼?封?銳

54、爽?封?銳爽?硼?繃封?EGCGEGCG?封?導?務?銳?務?銳?105?痰?告?嵴?EGCG?嵴?EGCGEGCG?嵴?嵴?模?封?務?務?嵴?模?嵴?嵴?撰?去?嵴?ESG銳爽?繃?繃?3.10?3.4?04?1024.1?+?TransepidermalHydration(?)?撰?Targeted?Collagen?Triggering(?贈?)?80%?贈?I?III?IV?Collagen?Conservation?Complex(?撐?紙?)?撰?8?EGCG?Empowered?Delivery(EGCG?)?撐?EGCG?Endogenous?Moisture(?)?MMPs

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