長壽革命：我們可以改變衰老的速度、基因還是生活方式導致了衰老.pdf

1、Presented by:2024 Longevity SummitEric Verdin,MDPresident and CEOBuck Institute for Research on AgingEric Verdin,CEO/President Buck Institute for Research on AgingThe Longevity RevolutionBreakthrough#1We can change the rate of aging4Modulation of Lifespan by Calorie RestrictionWe have identified con

2、served aging pathwaysExtendinghumanhealthspan:the futureSource:Varied/Axon Capital Partners research.In some cases these are median healthspan increases,and vary by stratificationNR (precursor to NMN&NAD)+5%Metformin+6%Acarbose+22%Rapamycin+26%Senescent cell clearance+35%FGF-21+36%GHRHKO+46%Axon Cap

3、ital Partners LtdThere are over 100 interventions that can extend the healthspan of a mouse.A number are in the clinic for humans but most have not yet been pursued as targets for drug development.Human Human TrialTrial ProgressProgressPhase IFDA Approved(Diabetes)FDA Approved(Diabetes)FDA Approved(

4、Organ Transplants)Phase IIPhase IIIPre-clinical researchBreakthrough#2Aging is the largest risk factor for non communicable diseasesBreakthrough#3Reinventing MedicineReinventing MedicineReinventing MedicineBreakthrough#4What drives aging:genes or lifestyle?93%non-genetic7%geneticGenetics,2018,210:11

5、09112416The 5 Pillars of AgingSome take home messagesWhat can I do today to maximize my healthspan and lifespan?We have a shorter life expectancy than almost all other high-income countries.The US spends the most in the world on healthcare yet ranks only 31st in life expectancy.Life Expectancy In Th

6、e USLife Expectancy In The US21Combined data from the Nurses Health Study&the Health Professionals Follow-up StudyThese studies followed 123,000 people over a 34-year periodData obtained through validated interviews,questionnaires,and self-reporting22A Prescription for adding 12+years of healthy lif

7、e23Low-risk Lifestyle FactorsRegular exerciseNo smokingHigh quality dietModerate alcohol consumptionHealthy weightRegular ExerciseMore than 3.5 hours/week(just a half hour a day!)of moderate to vigorous physical activity,including brisk walkingNo Smoking.Period.High Quality DietScore in the top 40%o

8、f the Alternate Healthy Eating Index(AHEI),which assigns scores based on how often you eat healthy or unhealthy foodsCreated by Harvard Medical School as a tool to reduce the risk of chronic diseaseA quick word on the AHEI5 servings of veggies/day+extra servings of green leafy veggies.Skip the fries

9、.4 servings of fruit/day.Avoid fruit juice.5-6 servings of whole grains/day1 serving/day of protein from nuts,legumes or tofuEat fish at least once/weekAdd healthy fats like olive oil and avocadoes.Skip the butter.Add these to your diet to up your score:Moderate Alcohol Consumption1 drink or less/da

10、y for women and 2 drinks or less/day for menHealthy WeightBMI within the healthy range of 18.5 to 24.9All that advice adds up!Adherence to a lowAdherence to a low-risk lifestyle=longer liferisk lifestyle=longer lifeCould prolong life expectancy at age 50 by Could prolong life expectancy at age 50 by 14.0 years for women and 12.2 years per men 14.0 years for women and 12.2 years per men compared with individuals without any of the compared with individuals without any of the lowlow-risk lifestyle factors.risk lifestyle factors.The bottom line:33The 5 Pillars of Aging