瑞絡科技-Subforum_VB100.pdf

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1、A Validated Solution for ADHD Assessment一個經臨床驗證的ADHD輔助診斷解決方案Rami HoreshCEO,Ruiluo Technology LtdAttention 注意Attention Problems usually impact academic achievements and are associated with poor grades,poor reading,and mathematics standardized test scores.Poor Attention may indicate the presence of At

2、tention Deficit Disorder(ADHD)which is associated with suspensions,anti-social behavior,and an increased rate of Mortality(4-fold).注意力問題通常會影響學業成績，并與成績差、閱讀差和數學考試成績有關。注意力不集中可能表明存在注意力缺陷障礙(ADHD)，這與輟學、反社會行為和死亡率增加（4倍）有關。Attention Profiling&ADHD Diagnosis 注意評估和ADHD診斷 Current measures:questionnaire based an

3、d no quantifiable test that objectively measures it and indicates an attention problem.當前評估方式：基于傳統量表，無客觀量化注意缺陷工具。About 13%of the population have attention difficulties,and the prevalence of Attention Deficit Disorder(ADHD)in China is estimated at 6.7%,however,less than 1%of cases are diagnosed.Hospi

4、tals are difficult to Reach,have Long Queues,are Costly,and of no capacity for wide screening.大約13%的人口有注意力困難，中國的注意力缺陷障礙(ADHD)患病率估計為6.7%，然而，不到1%的病例被診斷。目前存在專業醫療資源缺乏，難以獲取，就診預約時間長（3-6個月），費用高等問題。且醫院沒有精力進行社會面廣泛的篩查。Ruiluo is an innovative company providing remote healthcare solutions for Attention Profilin

5、g.A Cloud-based AI system is accessible at home,school,and outpatient clinics as well.瑞絡是一家創新的公司，為注意力分析提供遠程醫療解決方案?；谠朴嬎愕娜斯ぶ悄芟到y支持在家庭、學校和門診環境使用。Its parent company,Neurotech Solutions Ltd,an innovative Israeli company that is a global leader in the field of attention profiling,mainly for people who exh

6、ibit attentional difficulties and those who struggle with Attention Deficit Disorder(ADHD).它的母公司Neurotech Solutions Ltd是一家關注注意力困難和注意力缺陷障礙(ADHD)人群的以色列科技公司，所研發的技術在注意力分析領域處于全球領先地位。Guangzhou Ruiluo Technology Ltd.(“Ruiluo”瑞絡科技)Our Products 我們的產品SeeMe Attention Home and schools/家庭和學校環境使用(B2B,B2C)MOXO d-C

7、PTA professional clinical tool for the diagnosis of ADHD/ADHD 診斷的專業工具Kids Verions/兒童版本15-minute Test,for ages 6-12.Adults Version/成人版本,19-minute Test,ages 13 70.The Four Attentiveness Indices 四項注意指標Attentiveness-The ability to respond correctly and remain focused/正確反應Timeliness-The ability to respon

8、d quickly and accurately/正確快速反應Impulsiveness-The tendency to respond hastily,before evaluating the situation/未識別目標刺激之前倉促反應Hyper-reactivity-A difficulty in regulation of motor responses/動作調節困難Some MOXO related Researches MOXO相關臨床研究1.MOXO CPT validation in the diagnosis of ADHD in children(Oxford Univ

9、ersity)/診斷ADHD過程中的有效性驗證（牛津大學）。2.Pilot study Objective measures of ADHD(IMAJ-Israel Medical Association Journal)/MOXO與其他CPT檢出ADHD的敏感度研究3.The effect of distractors in a CPT on ADHD diagnosis among adolescents(Journal of neuroscience methods,222,62-68)/引進視聽干擾物對CPT在診斷青少年ADHD的影響4.Nature of differences be

10、tween(ADHD),oppositional defiant disorder(ODD),and ASD(Autism)(Psychiatria i Psychologia Kliniczna)/MOXO在ADHD、ODD（對立違抗）與ASD（自閉癥）的鑒別診斷研究5.Study on Neurofeedback training effectiveness(Clinical EEG and Neuroscience,51(2)/MOXO 用于評估腦電回饋訓練的有效性評估6.Alpha-Linolenic Acid supplementation effect on ADHD sympto

11、ms(Frontiers in human neuroscience,8,780)/MOXO用于Omega-3脂肪酸對ADHD癥狀改善效果的評估1.MOXO CPT validation in the diagnosis of ADHD in childrenMOXO CPT在兒童ADHD診斷中的驗證The purpose of this study was to evaluate the use of CPTS incorporating environmental distraction stimuli in supporting the diagnosis of ADHD in chil

12、dren.798 children aged 7-12 years(493 boys and 305 girls).The ADHD group included 339 children,while the control group included 459 children without ADHD.Berger,I.,Slobodin,O.,&Cassuto,H.(2017).Usefulness and validity of continuous performance tests in the diagnosis of attention-deficit hyperactivit

13、y disorder children.Archives of Clinical Neuropsychology,32(1),81-93.本研究的目的是評估納入環境干擾刺激的CPT在支持兒童多動癥診斷中的使用情況。參與者為798名7-12歲兒童（493名男孩和305名女孩）。ADHD組包括339名兒童，而對照組包括459名非多動癥兒童。In tests of the diagnostic utility of MOXO,specificity and sensitivity of MOXO were 85%or higher in all age groups.文中指出，在MOXO的診斷效用檢

14、驗中，在所有年齡組中，MOXO的特異性和敏感性均為85%或更高。AUC of 4 indexes achieves high values.The details is as below:專注力（A）參數的AUC值介于0.75和0.91之間反應速度（T）參數為0.80和0.90多動性（H）為0.73和0.82沖動性（I）參數顯示AUC在0.58和0.65之間。1.MOXO CPT validation in the diagnosis of ADHD in childrenMOXO CPT在兒童ADHD診斷中的驗證2.Pilot study Objective measures of ADHD

15、試點研究：MOXO對ADHD的客觀評估以往的CPT假陰性較高，本研究旨在探究測試新工具（CPF，本研究中使用的是MOXO）的信效度。該測試共收集了58名6-12歲的兒童的數據：45名被診斷為ADHD，13名非ADHD兒童作為對照組。Berger,I.,&Goldzweig,G.(2010).Objective measures of attention-deficit/hyperactivity disorder:a pilot study.IMAJ-Israel Medical Association Journal,12(9),531.The false negative rate was

16、 found high in other CPTs and the purpose of this study was to explore the reliability and validity of testing a new tool(CPF,MOXO was used in this study).A total of 58 children aged 6-12 were collected for the test:45 diagnosed with ADHD and 13 non-ADHD children served as a control group.It was fou

17、nd that MOXOs true positive detection rate for ADHD reached 100%.The other three CPT tests were 52%,75%and 64%,respectively.In addition,the comparison between the experimental group and the control group in four dimensions was statistically significant.文中指出，MOXO對ADHD真陽性的檢測率達到了100%。而其他三款CPT測試則分別為52%，

18、75%，64%。另外，實驗組和控制組在4個維度上的比對均在統計學上具備顯著性。2.Pilot study Objective measures of ADHD試點研究：MOXO對ADHD的客觀評估3.The effect of distractors in a CPT on ADHD diagnosis among adolescentsMOXO所引入的干擾刺激對在青少年持續注意和ADHD的診斷效果研究This study investigated the effects of adding intrusive stimuli to CPT on sustained attention and

19、 ADHD diagnosis in adolescents.The participants were 176 adolescents aged 13-18,133 diagnosed with ADHD and 43 without ADHD本研究探討了在CPT中加入干擾刺激對青少年持續注意和ADHD診斷的影響。參與者為176名13-18歲的青少年，133名被診斷為患有ADHD，43名沒有ADHD。Berger,I.,&Cassuto,H.(2014).The effect of environmental distractors incorporation into a CPT on s

20、ustained attention and ADHD diagnosis among adolescents.Journal of neuroscience methods,222,62-68.如圖表所示，多動癥青少年比未受影響的同齡人表現出更高的遺漏錯誤率。而組內分析表明，在多動癥組中，存在視覺干擾物以及視覺和聽覺干擾物的情況下，遺漏錯誤顯著高于無干擾物的情況。但與無干擾源相比，純聽覺干擾源的存在不會增加遺漏錯誤的數量。這也證明了，將視、聽干擾因素納入CPT有助于ADHD的診斷。The presence of pure auditory interference sources does

21、not increase the number of error omissions compared to non-interference sources.This also proves that the inclusion of visual and auditory disturbances in CPT is helpful for the diagnosis of ADHD.3.The effect of distractors in a CPT on ADHD diagnosis among adolescentsMOXO所引入的干擾刺激對在青少年持續注意和ADHD的診斷效果研

22、究4.Differential analysis between(ADHD),oppositional defiant disorder(ODD),and ASD(Autism)ADHD、對立違抗性障礙(ODD)與ASD(自閉癥)的鑒別診斷分析This study examines the specific nature of differences in attention deficit/hyperactivity disorder(ADHD),oppositional defiant disorder(ODD),and high-functioning Autism(Autism)com

23、pared to typically developing children.A total of 108 children ages 7 to 12 participated in the study,including 21 with oppositional defiant disorder,21 with high-functioning autism,and 19 with attention deficit/hyperactivity disorder.47 people served as the control group.本研究探討注意力缺陷/多動障礙（ADHD）、對立違抗障

24、礙（ODD）和高功能自閉癥（Autism）與典型發育兒童相比的具體性質差異。共108名7-12歲的兒童參與了這項研究，其中21名為對立違抗性障礙，21名為高功能自閉癥，19名為注意力缺陷/多動障礙；47人成為對照組。Borkowska,A.R.(2016).The dynamics of attentional and inhibitory functions in the presence of distracting stimuli in children with attention-deficit/hyperactivity disorder,high-functioning auti

25、sm and oppositional defiant disorder.Psychiatria i Psychologia Kliniczna,16(2),68-80.The results showed that there were significant differences between ADHD and control group in the four dimensions of MOXO.There was also a significant difference between oppositional defiance(ODD)and control groups.I

26、t indicates that MOXO also has certain discriminative ability for some other functional disorders or diseases.結果顯示，MOXO的4個維度在ADHD和對照組的比對上均有顯著差異。且對立違抗（ODD）和對照組的比對也同樣顯著差異。說明MOXO對于部分其他的功能障礙或疾病也具備一定的鑒別能力。4.Differential analysis between(ADHD),oppositional defiant disorder(ODD),and ASD(Autism)ADHD、對立違抗性障礙

27、(ODD)與ASD(自閉癥)的鑒別診斷分析本研究探討了個體化神經反饋訓練對ADHD兒童工作記憶的長期作用。48名患有ADHD的兒童（6-12歲）被隨機分配到神經反饋組和控制組。Dobrakowski,P.,&ebecka,G.(2020).Individualized neurofeedback training may help achieve long-term improvement of working memory in children with ADHD.Clinical eeg and Neuroscience,51(2),94-101.This study investiga

28、ted the long-term effects of individualized neurofeedback training on working memory in children with ADHD.48 children(6-12 years old)with ADHD were randomly assigned to neurofeedback or control groups.5.Study on Neurofeedback training Is it effective？關于神經反饋的研究它有效嗎？This study found that the frequenc

29、y of theta and beta training resulted in significant improvements in working memory in children who received 10 to 12 sessions of neurofeedback training within 10 weeks.And those beneficial effects persisted a year after the training.In this study,MOXO was used to test the experimental effect.It can

30、 be seen that the n-back test performance of children with small deviation of Z-scores has a better trend;The less severe the ADHD symptoms,the better the performance.And the results diverged significantly,with eight subjects with Z-scores of 0.825 or higher responding correctly 65%to 69%of the time

31、,while those with scores below 0.825 responded correctly only 27%to 39%of the time.這項研究發現，在接受10周內、10到12次神經反饋訓練的兒童中，theta和beta的訓練頻率對工作記憶有顯著改善。且這些有益的效果在訓練一年后仍然存在。該研究中，MOXO用于檢驗實驗效果?？梢钥吹絲分數偏差較小的兒童的n-back測試表現有較好的趨勢；即ADHD癥狀越輕，表現越好。能看到結果分化非常明顯，z分數不低于0.825的8名受試者有65%到69%的正確應答率，而得分低于0.825的受試者則只有27%到39%的正確應答率。

32、5.Study on Neurofeedback training Is it effective？關于神經反饋的研究它有效嗎？This study investigated the effect of supplementation of omega-3 fatty acids on ADHD symptoms in children.40 untreated ADHD children,ages 6-16,were randomly assigned to receive 2g/day of sage oil or placebo,2g of sage oil with 1g of ome

33、ga-3 fatty acids for 8 weeks.Dubnov-Raz,G.,Khoury,Z.,Wright,I.,Raz,R.,&Berger,I.(2014).The effect of alpha-linolenic acid supplementation on ADHD symptoms in children:a randomized controlled double-blind study.Frontiers in human neuroscience,8,780.本研究探討了補充omega-3脂肪酸對兒童ADHD癥狀的影響。40名未經治療的ADHD兒童，年齡在6-1

34、6歲，被隨機接受2 g/天的鼠尾草油或安慰劑含，2g鼠尾草油含1g omega-3脂肪酸的，為期8周。6.The effect of alpha-linolenic acid supplementation on ADHD symptomsOmega-3脂肪酸對ADHD癥狀的影響該研究的結論為補充2g/天含1g Omega-3脂肪酸的鼠尾草油，并不能顯著減輕ADHD兒童的癥狀。兒童補充脂肪酸前后，與Conners量表的結果一致，MOXO數據當中，研究組之間的任何測試參數都沒有顯著差異。此外，在任何測量中，從補充前到補充后的變化都沒有顯著差異。The study concluded that s

35、upplementation with 2g of sage oil containing 1g ALA per day did not significantly reduce symptoms in children with ADHD.Before and after fatty acid supplementation in children,consistent with Conners scale results,there were no significant differences in any test parameters between the study groups

36、 in the MOXO data.In addition,there was no significant difference in changes from before to after supplementation in any of the measurements.6.The effect of alpha-linolenic acid supplementation on ADHD symptomsOmega-3脂肪酸對ADHD癥狀的影響Researches Conclusion 研究小結MOXO CPT is a validated tool in the diagnosi

37、s of ADHD in children.It is fast,easy to use,and provides quantified results.It allows at a very low cost to perform a high variety of research from different angels.As our database is growing the accuracy and possibilities are improving.We will be happy to consider cooperation with relevant institutes.MOXO CPT是經臨床驗證用于診斷兒童ADHD的有效工具?？焖俸Y查，易于使用，并提供量化的評估結果。它允許以較低的成本從不同的角度進行各種各樣的研究。隨著我們數據庫的增長，準確性和技術延展的可能性也在提高。歡迎相關機構與我們開展商業和技術合作。Thank you for your Attention