從數據到發現：GenAI 如何改變生物信息學.pdf

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1、10.12.2024From Data to Discovery:How GenAI is Changing BioinformaticsIris Wing To Lam Co-founder and CEO,Genie TechBioWorld Summit AI Qatar2AgendaWhy Bioinformatics(BFX)?My personal experienceApplications of GenAI in BFXFuture Potential of GenAI in BFXConclusion1.2.3.4.5.3AgendaWhy Bioinformatics(BF

2、X)?My personal experienceApplications of GenAI in BFXOutlook and Conclusion1.2.3.4.4Bioinformatics is an interdisciplinary field that combines biology,computer science,and mathematics to analyze and interpret complex biological data.Why Bioinformatics(BFX)?5Think of bioinformatics as the Google Maps

3、 for biological research it helps scientists navigate through vast amounts of data to find their destination:understanding diseases.Why Bioinformatics(BFX)?Understanding Virus Structure and FunctionBy utilizing genomic sequencing,researchers were able to identify viral genes and proteins that could

4、serve as targets for vaccine development.6Why Bioinformatics(BFX)?Wacharapluesadee,S.,Tan,C.W.,Maneeorn,P.et al.Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia.Nat Commun 12,972(2021).https:/doi.org/10.1038/s41467-021-21240-1Identifying Immune Respon

5、sesTranscriptomics and proteomics provided insights into how the immune system responds to vaccination.7Why Bioinformatics(BFX)?Wendisch D,Dietrich O,Mari T,et al.SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.Cell.2021;184(26):6243-6261.e27.doi:10.1016/j.cell.2021.

6、11.033Accelerating Antigen Discovery Viral genome sequences,transcriptomic and proteomic data allowed researchers to identify specific antigens from the SARS-CoV-2 virus that could elicit a strong immune response.8Why Bioinformatics(BFX)?Ong,E.Z.,Yee,J.X.,Ooi,J.S.G.et al.Immune gene expression analy

7、sis indicates the potential of a self-amplifying Covid-19 mRNA vaccine.npj Vaccines 7,154(2022).https:/doi.org/10.1038/s41541-022-00573-yGuiding Vaccine DesignOmics analysis helped researchers understand how to induce long-lasting immunity,which is essential for effective vaccination strategies.9Why

8、 Bioinformatics(BFX)?Cheong JG,Ravishankar A,Sharma S,et al.Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.Cell.2023;186(18):3882-3902.e24.doi:10.1016/j.cell.2023.07.01910Bioinformatics enables faster,more accurate vaccine and drug design,leading to improved

9、patient outcomes.Why Bioinformatics(BFX)?11AgendaWhy Bioinformatics(BFX)?My personal experienceApplications of GenAI in BFXOutlook and Conclusion1.2.3.4.12AgendaScience PresentationDefining the ProblemMaking ObservationsForming a HypothesisExperiment ResultsDrawing a Conclusion1.2.3.4.5.13There is a

10、 shortage of skilled bioinformaticians,and its delaying the progress of biomedical research.My personal experience14My personal experience15My personal experience16My personal experience17My personal experience18My personal experience19Genie TechBio harnesses the power of GenAI to unlock access to c

11、omplex yet powerful bioinformatics tools to make research faster,cheaper and more reproducible.My personal experience20AgendaWhy Bioinformatics(BFX)?My personal experienceApplications of GenAI in BFXOutlook and Conclusion1.2.3.4.Drug Discovery and DevelopmentInsilico Medicine has pioneered the use o

12、f generative adversarial networks(GANs)for de novo drug design,integrating advanced AI methodologies into their drug discovery processes.They consist of two neural networks,the generator and the discriminator,which engage in a competitive process to improve their performance.This architecture allows

13、 GANs to generate realistic data that closely resembles a given training dataset.This approach allows for the rapid identification and synthesis of novel drug candidates,significantly accelerating the timeline and reducing costs associated with traditional drug development.21Applications of GenAI in

14、 BFXProtein EngineeringGoogle DeepMind has introduced AlphaProteo,a tool for designing novel proteins that can bind effectively to target molecules.This innovation illustrates how GenAI can facilitate the engineering of proteins for therapeutic purposes.22Applications of GenAI in BFX23AgendaWhy Bioi

15、nformatics(BFX)?My personal experienceApplications of GenAI in BFXOutlook and Conclusion1.2.3.4.24Outlook and ConclusionWell see drug candidates generated in mere days instead of years,and clinical trials that adapt in real-time based on patient responses.25Outlook and ConclusionThis accessibility will fundamentally speed up biomedical research,enabling scientists to focus on discovery rather than data bottlenecks.10.12.2024Iris Wing To Lam Co-founder and CEO,Genie TechBWorld Summit AI Qatar