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表4、BTKPROTAC在CLL的臨床數據對比-行業數據

表4、BTKPROTAC在CLL的臨床數據對比
表4、BTKPROTAC在CLL的臨床數據對比
BTK抑制劑治療可能導致獲得性耐藥突變，尤其是 BTK的 C481S突變，會使得這類共價抑制劑的治療效果降低，急需開發針對 BTK抑制劑耐藥的療法。
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表4、BTKPROTAC在CLL的臨床數據對比_第1頁
表4、BTKPROTAC在CLL的臨床數據對比_第2頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第3頁
表4、BTKPROTAC在CLL的臨床數據對比_第4頁
表4、BTKPROTAC在CLL的臨床數據對比_第5頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第6頁
表4、BTKPROTAC在CLL的臨床數據對比_第7頁
表4、BTKPROTAC在CLL的臨床數據對比_第8頁
表4、BTKPROTAC在CLL的臨床數據對比_第9頁
表4、BTKPROTAC在CLL的臨床數據對比_第10頁
表4、BTKPROTAC在CLL的臨床數據對比_第11頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第12頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第13頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第14頁
表4、BTKPROTAC在CLL的臨床數據對比_第15頁
表4、BTKPROTAC在CLL的臨床數據對比_第16頁
表4、BTKPROTAC在CLL的臨床數據對比_第17頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第18頁
表4、BTKPROTAC在CLL的臨床數據對比_第19頁
fCBFM+i/nuaOpemFtuexu+WeiyB8IEUz6L+e5o6l6YW256S65L6LIHwKfCAtLS0gfCAtLS0gfAp8IENOUy1lbnJpY2hlZCBFM3MgfCBUUklNOSwgUk5GMTgyLCBNYW55IG90aGVycyB8CnwgVHVtb3VyLWVucmljaGVkIEUzcyB8IERDQUYyLCBUUklNNzEsIE1BR0VzLCBNYW55IG90aGVycyB8CnwgTXVzY2xlLWVucmljaGVkIEUzcyB8IEtMSEw0MSwgS0xITDQwIHwKfCBVYmlxdWl0b3VzIEUzcyB8IENVTDRCLCBWSEwsIEdJRDQsIE1hbnkgb3RoZXJzIHwKCui1hOaWmeadpea6kO+8mkLDqWvDqXMgTSwgTGFuZ2xleSBEUiwgQ3Jld3MgQ00uIFBST1RBQyB0YXJnZXRlZCBwcm90ZWluIGRlZ3JhZGVyczogdGhl
表4、BTKPROTAC在CLL的臨床數據對比_第20頁
表4、BTKPROTAC在CLL的臨床數據對比_第21頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第22頁
表4、BTKPROTAC在CLL的臨床數據對比_第23頁
表4、BTKPROTAC在CLL的臨床數據對比_第24頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第25頁
表4、BTKPROTAC在CLL的臨床數據對比_第26頁
表4、BTKPROTAC在CLL的臨床數據對比_第27頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第28頁
fCDoja/lk4HlkI3np7AgfCDnoJTlj5HmnLrmnoQgfCDnlr7nl4UgfCDlhajnkIPmnIDpq5jnoJTlj5HpmLbmrrUgfAp8IC0tLSB8IC0tLSB8IC0tLSB8IC0tLSB8CnwgY2F0ZGVnaXJ1dGluaWIgfCDnmb7mtY7npZ7lt54gfCDmhaLmgKfmt4vlt7Tnu4bog57nmb3ooYDnl4UgfCBJSUnmnJ/kuLTluoogfAp8IE5YLTIxMjcgfCBOdXJpeCBUaGVyYXBldXRpY3MgfCBC57uG6IOe5reL5be055ikIHwgSeacn+S4tOW6iiB8CnwgYmV4b2JydXRpbmliIHwgTnVyaXggVGhlcmFwZXV0aWNzIHwgQue7huiDnua3i+W3tOeYpCB8IEnmnJ/kuLTluoogfAp8IFVCWC0zMDMgfCBVYmx4IFRoZXJhcGV1dGljcyB8IELnu4bog57mt4vlt7TnmKQgfCBJ5pyf5Li05bqKIHwKfCBIU0syOTExNiB8IOa1t+aAneenkSB8IELnu4bog57mt4vlt7TnmKQgfCBJ5pyf5Li05bqKIHwKfCBIWi1RMTA3MCB8IOWSjOato+WMu+iNryB8IELnu4bog57mt4vlt7TnmKQgfCBJ5pyf5Li05bqKIHwKCui1hOaWmeadpea6kO+8muWMu+iNr+mtlOaWue+8jOWFtOS4muivgeWIuOe7j+a1juS4jumHkeiejeeglOeptumZouaVtOeQhu+8m+azqO+8muaVsOaNruaIquatouiHszIwMjXlubQ15pyIMjDml6XjgII=
表4、BTKPROTAC在CLL的臨床數據對比_第29頁
表4、BTKPROTAC在CLL的臨床數據對比_第30頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第31頁
表4、BTKPROTAC在CLL的臨床數據對比_第32頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第33頁
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
表4、BTKPROTAC在CLL的臨床數據對比_第34頁
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
所屬報告： 醫藥生物行業PROTAC深度報告：探索“不可成藥難題”的解決方案拓展腫瘤、自身免疫等領域市場潛力-250522（37頁）.pdf
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