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URAT1底物轉運與藥物抑制機制卡通模型圖-行業數據

URAT1底物轉運與藥物抑制機制卡通模型圖
URAT1底物轉運與藥物抑制機制卡通模型圖
不同的URAT1 抑制劑分子結構，對藥理特性會產生一定影響，根據 2024 年發表在《CellResearch》雜志上的研究成果顯示，研究團隊選擇 lesinurad（雷西納德）、verinurad 和dotinurad（多替諾雷）三款藥物與 URAT1 進行相互結合的冷凍電鏡研究，發現其與URAT1結構空間位點以及結合強度上會有所不同，可能是其最終藥理藥效產生不同的主要原因之一。
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