楊振-全健康視角下的全球豬病監測策略.pdf

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1、全全健健康康視視角角下下的的全全球球豬豬病病監監測測One Health Perspective of Global Swine Disease Monitoring and Surveillance楊楊振振 南南京京農農業業大大學學動動物物醫醫學學院院“一一帶帶一一路路”國國際際生生豬豬產產業業大大會會鄭鄭州州-河河南南 2024.4.26Zhen Yang Associate ProfessorCollege of Veterinary Medicine,Nanjing Agricultural UniversityE-mail： 一帶一路國際生豬產業大會2全健康One HealthOne

2、 Health is an integrated,unifying approach that aims to sustainably balance and optimize the health of people,animals and ecosystems.It recognizes the health of humans,domestic and wild animals,plants,and the wider environment(including ecosystems)are closely linked and inter-dependent.(OHHLEP One H

3、ealth definition,2021)One Health（全健康）是一種綜合的、統一的方法，旨在可持續地平衡和優化人類、動物和生態系統的健康。它認識到人類、家畜和野生動物、植物以及更廣泛的環境（包括生態系統）的健康是緊密相連和相互依賴的。（OHHLEP一健康定義，2021）一帶一路國際生豬產業大會因果網絡Web of causationCONTAMINANTSWhich include chemical residues,heavy metals.pharmaceuticals,disinfectants,bacteria,viruses,and protozoa.污染物 包括化學殘留

4、物、重金屬、藥品、消毒劑、細菌、病毒和原生動物。改遍自 Bennie I.Osburn博士Adapted from Dr.Bennie I.OsburnSOURCES All contaminants are of human,animal,or environmental origin.來源所有污染物都源自人類、動物或環境。SYSTEMContaminants entering ecosystems can negatively impact the health of humans,animals,and the environment.系統污染物進入生態系統可能對人類、動物和環境的健康產

5、生負面影響。ROUTES Contaminants enter ecosystems via routes both directly or indirectly途徑:污染物通過直接或間接的途徑 進入生態系統。Animals 動物People 人Equipment 設備Water 水Wind 風Soil 土壤一帶一路國際生豬產業大會Global distribution of pigs全全球球生生豬豬分分布布(head per square kilometer)Extensive (a):100 Data Source:FAOSTAT,National GDP estimateChina 20

6、10 NBS,etc.Gilbert M,Conchedda G,Van Boeckel TP,Cinardi G,Linard C,et al.(2015)Income Disparities and the Global Distribution of Intensively Farmed Chicken and Pigs.PLOS ONE 10(7):e0133381.https:/doi.org/10.1371/journal.pone.0133381https:/journals.plos.org/plosone/article?id=10.1371/journal.pone.013

7、3381ABC生生豬豬生生產產Global swine production一帶一路國際生豬產業大會Source:Robinson et al.,2014一帶一路國際生豬產業大會全球豬肉消費Global animal protein consumption 亞洲的豬肉文化Pork culture in Asia Viet Nam:Tet,Thit Heo Quay(crispy pork belly)Republic of Korea:Korean Barbeque,SamgyeopsalThe Philippines:LechonJapan：Ramen,TonkatsuCambodia:Ba

8、i Sach ChroukChina:“meat=pork”Source:FAO 一帶一路國際生豬產業大會Pork consumption,kg/person,2019Source：OECD ilibrary 一帶一路國際生豬產業大會2018-2020 全球豬肉生產價格波動-非洲豬瘟2018-2020 Global Hog Market-ASF0501001502002503002018.01.222018.02.132018.03.122018.04.302018.05.312018.06.262018.07.192018.08.222018.09.132018.10.112018.11.1

9、82019.01.042019.01.232019.02.112019.03.192019.05.022019.06.112019.07.082019.07.242019.08.282019.09.182019.10.182019.11.062019.11.272019.12.182020.01.082020.02.052020.03.112020.04.012020.04.282020.05.202020.06.172020.07.082020.07.312020.08.252020.09.17USACanadaMexicoBrazilRussiaChinaSpainFrance Unite

10、d KingdomViet NamRepublic of KoreaRepublic of Korea Viet NamChinaRepublic of KoreaViet NamChinaData source：Genesus global market report一帶一路國際生豬產業大會豬肉生產的動態-疫病的影響Dynamic Global pork production-disease impactData source:USDA0200004000060000800001000001200002016201720182019.42019.72020.42020.7豬肉生產Pork p

11、roduction（1,000 metric tons)ChinaOther countries and territories一帶一路國際生豬產業大會規模豬場崛起Multi-storey buildings “hog hotel”一帶一路國際生豬產業大會Muyuan Food Mega Pig Farms 8 4000 sows2.1 million market pigs一帶一路國際生豬產業大會疾病復雜性Complexity of diseasehttp:/www.gf-tads.org/about/en/亞洲一帶一路國際生豬產業大會疾病傳播的復雜性 Complexity of disea

12、se transmissionSource：FAO ASF diagnostic manual 一帶一路國際生豬產業大會疾病監測和早期預警Disease surveillance and early warning Source:Changing Disease Landscape(World of Livestock 2013;FAO)一帶一路國際生豬產業大會WOAH WHAISWOAH-WAHIS(World Animal Health Information System)is a unique comprehensive database through which informati

13、on on the animal health situation worldwide is reported and disseminated throughout the world.WOAH-WAHIS data reflects the information gathered by the Veterinary Services from WOAHMembers and non-Members Countries and Territories on WOAH-listed diseases in domestic animals and wildlife,as well as on

14、 emerging diseases and zoonoses.一帶一路國際生豬產業大會一帶一路國際生豬產業大會一帶一路國際生豬產業大會一帶一路國際生豬產業大會Web based disease information 開開源源疾疾病病信信息息EIOShttps:/www.oie.int/eng/BIOTHREAT2017/Presentations/6.2_BARBOZA-presentation.pdf一帶一路國際生豬產業大會Web based disease information 開開源源疾疾病病信信息息Pro Med International Society for Infecti

15、ous Diseasehttps:/promedmail.org/一帶一路國際生豬產業大會國家水平上的豬病監測 Swine disease surveillance at national level Source:MAFRA Animal and Plant Quarantine Agency The Ministry of Agriculture,Food and Rural Affairs(MAFRA)一帶一路國際生豬產業大會01002003004005006007008002019/10/32019/10/172019/10/312019/11/142019/11/282019/12/

16、122019/12/262020/1/92020/1/232020/2/62020/2/202020/3/52020/3/192020/4/22020/4/162020/4/302020/5/142020/5/282020/6/112020/6/252020/7/92020/7/232020/8/62020/8/202020/9/32020/9/172020/10/1野豬ASF病例數日期（數據時間間隔兩周）ASF cases in wild boars in ROK韓韓國國野野豬豬ASF病病例例數數江江原原道道京京畿畿道道*2020.04.12：9,070頭野豬樣品，2365死野豬，510頭A

17、SF陽性（21.6%），捕獲野豬6714，19頭陽性（0.2%）；19年10月至20年3月死野豬ASF陽性率5.5-33.9%，捕獲野豬陽性率01.-0.5%一帶一路國際生豬產業大會韓國野豬非洲豬瘟監測ASF surveillance in wild boars in Republic of Korea結論來源：https:/world.kbs.co.kr/service/news_view.htm?lang=k&Seq_Code=354330一帶一路國際生豬產業大會越南ASF監測ASF situation in Viet NamMinistry of Agriculture and Rura

18、l Development(MARD)confirmed its first ASF outbreak on 19 February 2019農業和農村發展部（MARD）于2019年2月19日確認了首次非洲豬瘟（ASF）疫情暴發。All 63 provinces/municipalities experienced outbreaks.所有63個省/市均經歷了疫情。ASF endemics 非洲豬瘟地方流行 一帶一路國際生豬產業大會越南ASF監測ASF situation in Viet Nam2021.07.06Provinces where no new ASF outbreaks for

19、 more than 30 days(blue)in Viet NamSource：FAO ASF situation update in Asia and Pacific 一帶一路國際生豬產業大會越南ASF監測ASF situation in Viet Nam 2019-202001,0002,0003,0004,0005,0006,0007,0008,0009,00010,00019 Feb05 Mar19 Mar02 Apr16 Apr30 Apr14 May28 May11 Jun25 Jun09 Jul23 Jul06 Aug20 Aug03 Sep17 Sep01 Oct15 Oc

20、t29 Oct12 Nov26 Nov10 Dec24 Dec07 Jan21 Jan04 Feb18 Feb03 Mar17 Mar31 Mar14 Apr28 AprOutbreaks that were not over 30 daysOutbreaks that were over 30 daysCumulative number of affected communes/week in Viet Nam(Calculated figure)Source:FAO；OCHA:Vietnam:Floods DREF operation n MDRVN018-Final ReportUnit

21、ed Nations Office for the Coordination of Humanitarian AffairsAugust 2019,Mid central,the central highlands and several provinces in southern Vietnam were flooded一帶一路國際生豬產業大會區區域域監監測測Regional surveillanceSource：FAO ASF situation update in Asia and Pacific China(3 August 2018)Mongolia (15 January 2019

22、)Vietnam(19 February 2019)Cambodia (April 2019)Democratic Peoples Republic Korea(15 January 2019)Laos Peoples Democratic Republic(20 June 2019)Myanmar(1 August 2019)Republic of Korea(17 September 2019)The Philippines(July 2019)Timor-Leste(27 September)Indonesia(2019)Papua New Guinea(March 2020)India

23、(Jan Apr 2020)Malaysia(February 2021)Bhutan(May 2021)一帶一路國際生豬產業大會MSHMP全全國國豬豬群群疾疾病病監監測測一帶一路國際生豬產業大會行業豬病監測Swine disease monitoring and surveiliance依依托托可可被被信信任任的的非非商商業業機機構構和和團團隊隊進進行行行行業業非非敏敏感感疾疾病病數數據據匯匯總總和和分分析析，找找出出全全國國的的疫疫病病發發病病規規律律是是可可能能的的！一帶一路國際生豬產業大會行業診斷實驗室疾病監測Disease surveillance Data from VDLs一帶一

24、路國際生豬產業大會非瘟背景下的多種對象的監測Multiple surveillance objectives Pre-ASF era 豬 Post-ASF era 豬 人、車、物資 水、飼料、空氣.一帶一路國際生豬產業大會傳染病和生物安全知識的普及提升了行業對豬病風險的認識Farm ProcessesWaste 排排泄泄物物Garbage 垃垃圾圾Mortalities 死死豬豬后后備備Gilts公公豬豬Boars精精液液SemenBreeding Stock種種豬豬Commercial pigs商商品品豬豬水水 Water飼飼料料 Feed人人 People物物資資 Supplies設設備備

25、 Equipment害害蟲蟲/獸獸 Pests空空氣氣 Air一帶一路國際生豬產業大會飼料風險與檢測 Feed risk and test一帶一路國際生豬產業大會車輛風險與檢測Truck risk and test一帶一路國際生豬產業大會氣溶膠風險與檢測Aerosols risk and testScott Dee一帶一路國際生豬產業大會氣溶膠風險與檢測Aerosols risk and test一帶一路國際生豬產業大會人員和物資People and supply一帶一路國際生豬產業大會其他風險Other risks一帶一路國際生豬產業大會其他風險監測 Other risks surveili

26、ance一帶一路國際生豬產業大會疑惑與挑戰Questions and challenges如何設計的豬病監測計劃？How to design a swine disease monitoring program?在豬群、農場、區域等不同層面，選什么監測指標?What monitoring indicators should be selected at different levels such as the pig herd,farm,and regional?如何增大檢測效率？如何增大敏感性和特異性？如何避免假陰性和假陽性？如何解讀我們數據？How to increase detectio

27、n efficiency?How to enhance sensitivity and specificity?How to avoid false negatives and false positives?How should we interpret our data?疾病監測和檢測項目給我們帶來的價值是什么？What value do disease monitoring and testing programs bring to us?一帶一路國際生豬產業大會車輛和飼料監測-案例 Case demo Truck and feed surveillance一帶一路國際生豬產業大會A A

28、體體系系2 20 02 21 1年年至至2 20 02 24 4年年車車輛輛采采樣樣陽陽性性率率S ST TL L分分解解結結果果B B體體系系2 20 02 21 1年年至至2 20 02 24 4年年車車輛輛采采樣樣陽陽性性率率S ST TL L分分解解結結果果7-12月10-3月車輛監測趨勢分析Truck surveillance analysis*研究生：王文哲一帶一路國際生豬產業大會飼料監測趨勢Trend in feed risk surveillance某體系2021年至2024年飼料及飼料廠采樣陽性率STL分解結果*研究生：王文哲一帶一路國際生豬產業大會未來思考Thoughts

29、on future directions監測對象：內部和外部：豬，人，車，物，料，水，氣，野生動物、害獸/蟲、周邊環境.監測手段：癥狀檢測、分子檢測、圖像識別、人工智能監測范圍：豬-場-區-域 明確監測時間、頻率和優先級趨勢和預警分析 豬群、場、體系和區域的數據整合分析挑戰 數據搜集和質量 數據分享和保密 數據分析和解讀一帶一路國際生豬產業大會謝謝！Thanks for your attention！Zhen Yang,DVM,MS,Associate Professor College of Veterinary Medicine,Nanjing Agricultural UniversityE-mail： WeChat ID:yz_Gavin“一一帶帶一一路路”國國際際生生豬豬產產業業大大會會鄭鄭州州-河河南南 2024.4.26一帶一路國際生豬產業大會